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Epidemiology of Celiac Disease

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Celiac Disease

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

Celiac disease (CD) is a chronic small intestine immune-mediated enteropathy triggered by exposure to gluten in genetically sensitive individuals (DQ2+ or DQ8+). Gluten is a protein component found in wheat, barley, and rye but not in oats. The CD-related enteropathy is characterized by small intestinal villous atrophy and crypt hyperplasia. These mucosal aberrations most often resolve on a gluten-free diet (GFD). The GFD is currently the only available treatment for CD, although ongoing pharmacological and vaccine trials promise future alternatives.

In this chapter, we review current knowledge about classification and diagnosis of CD, including its prevalence and incidence.

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Authors and Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17176, Sweden

    Jonas F. Ludvigsson M.D., Ph.D.

  2. Örebro University Hospital, Örebro, Sweden

    Jonas F. Ludvigsson M.D., Ph.D.

  3. Department of Internal Medicine, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

    Federico Biagi M.D. & Gino Roberto Corazza M.D.

Authors
  1. Jonas F. Ludvigsson M.D., Ph.D.
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  2. Federico Biagi M.D.
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  3. Gino Roberto Corazza M.D.
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Correspondence to Jonas F. Ludvigsson M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

    S. Devi Rampertab

  2. Department of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerard E. Mullin

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Ludvigsson, J.F., Biagi, F., Corazza, G.R. (2014). Epidemiology of Celiac Disease. In: Rampertab, S., Mullin, G. (eds) Celiac Disease. Clinical Gastroenterology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8560-5_3

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