Abstract
Solid lipid extrusion takes place some Kelvin below the melting point or melting range of the lipid. Depending on the melting point of the lipid, the extrusion can be performed at room temperature or up to approximately 70 °C. Plasticity is achieved by a thermomechanical treatment of the lipids without melting the bulk part of the lipid. The extrusion process is simple and robust and can be integrated with several downstream processes into a continuous production. Solid lipid extrusion is a solvent-free process, which is suitable for thermosensitive drugs. Solid lipid extrudates and solid dosage forms made by these extrudates can be used to modify the dissolution profile of the active pharmaceutical ingredient (API). The dissolution profiles of the cut, milled, or spheronised extrudates can be tailored in a wide range and are mechanistically understood. In particular, a prolonged release can be achieved without any further coating of the particles. The topics formulation, processing, physical stability, dissolution profiles including their modelling and pharmaceutical applications of solid lipid extrudates are addressed.
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Kleinebudde, P. (2013). Solid Lipid Extrusion. In: Repka, M., Langley, N., DiNunzio, J. (eds) Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8432-5_13
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DOI: https://doi.org/10.1007/978-1-4614-8432-5_13
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