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Chronic Inflammatory Bowel Disease in Remission: Mucosal Neoplasias

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Early Neoplasias of the Gastrointestinal Tract

Abstract

Colonoscopic surveillance for risk of colorectal cancer (CRC) associated with inflammatory bowel disease (IBD) is recommended annually beginning at 8 years disease duration in ulcerative pancolitis and Crohn’s colitis. Family history of sporadic CRC raises the risk of CRC by twofold, association with primary sclerosing cholangitis by fourfold. Optimized conditions for endoscopy, random and targeted biopsy requirements, and patient information and compliance are essential for success of the surveillance program, as well as experienced endoscopic detection and classification of neoplastic lesions: (a) sporadic lesions (in uninvolved colon) and in involved bowel (b) adenomatous dysplasia-associated lesions or mass (DALM), (c) non-adenoma-like DALM, and (d) flat dysplasia. Endoscopic en bloc resection (with free margins) is recommended for lesions (a and b), whereas sphincter-preserving colectomy for (c) non-adenoma-like DALM and (d) flat dysplasia.

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Acknowledgments

The contribution of some cases by Dr. Gerhard Kleber/Aalen, Germany; Dr. Andrej Wagner/Salzburg, Austria; and Dr. Naohisa Yahagi, Keio Univ. Medical School/Tokyo, Japan, and evaluation of histology by Dr. Daniel Neureiter/Salzburg, Austria, are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Internal Medicine, Gastroenterology and Oncology, St. Marienkrankenhaus Frankfurt, Richard-Wagner-Strasse 14, 60318, Frankfurt am Main, Germany

    Ralf Kiesslich

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  1. Ralf Kiesslich
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Correspondence to Ralf Kiesslich .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine I, Paracelsus Medical University/Salzburger, Landeskliniken, Salzburg, Austria

    Frieder Berr

  2. Department of Endoscopy, Saku Central Hospital, Advanced Care Center, Saku, Nagano, Japan

    Tsuneo Oyama

  3. Department of Digestive Diseases, HĂ´pital Eduard Herriot, Lyon, France

    Thierry Ponchon

  4. Division of R&D for Minor Invasive Treatment, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

    Naohisa Yahagi

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Kiesslich, R. (2014). Chronic Inflammatory Bowel Disease in Remission: Mucosal Neoplasias. In: Berr, F., Oyama, T., Ponchon, T., Yahagi, N. (eds) Early Neoplasias of the Gastrointestinal Tract. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-8292-5_11

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  • DOI: https://doi.org/10.1007/978-1-4614-8292-5_11

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-8291-8

  • Online ISBN: 978-1-4614-8292-5

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