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Negative Regulation for Neural Patterning in the Drosophila eye

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Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

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Abstract

The Drosophila compound eye is a complex sensory system derived from retinal primordium called the eye imaginal disc. Differentiation of the retinal primordium into different cell types is a key to the visual function of the eye. The fly eye has a simple structure with only a few cell types and a precise organization with a repetitive pattern, thus serving as a favorable model for studying the genetic basis of retinal patterning. An important early event in retinal differentiation is the generation and assembly of neural precursor cells. A number of genes and multiple signaling pathways participate in this process. Many of these genes are involved in promoting the neural differentiation. However, retinal neurogenesis also requires a number of negative factors. Thus, early patterning in the eye is established by interactions between these yin–yang gene activities. This chapter will describe the function of these genetic factors, focusing more on negative regulators that help develop the precise pattern of the adult eye.

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Authors and Affiliations

  1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 305–701, Rep. of Korea

    Kwang-Wook Choi

  2. Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 305–701, Rep. of Korea

    Kwang-Wook Choi

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  1. Department of Biology, University of Dayton, Dayton, Ohio, USA

    Amit Singh

  2. Department of Biology Office: SC303C, University of Dayton, Dayton, Ohio, USA

    Madhuri Kango-Singh

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Choi, KW. (2013). Negative Regulation for Neural Patterning in the Drosophila eye. In: Singh, A., Kango-Singh, M. (eds) Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8232-1_6

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