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ROUNDABOUT Receptors

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Cell Adhesion Molecules

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 8))

Abstract

Roundabout receptors (Robo) and their Slit ligands were discovered in the 1990s and found to be key players in axon guidance. Slit was initially described as an extracellular matrix protein that was expressed by midline glia in Drosophila. A few years later, it was shown that, in vertebrates and invertebrates, Slits acted as chemorepellents for axons crossing the midline. Robo proteins were originally discovered in Drosophila in a mutant screen for genes involved in the regulation of midline crossing. This ligand–receptor pair has since been implicated in a variety of other neuronal and non-neuronal processes ranging from cell migration to angiogenesis, tumourigenesis and even organogenesis of tissues such as kidneys, lungs and breasts.

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  1. Institut de la Vision, INSERM UMRS 968, CNRS UMR 7210, 17 Rue Moreau, Paris, 75012, France

    Athéna R. Ypsilanti Ph.D. & Alain Chedotal Ph.D., DR1 INSERM.

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    Vladimir Berezin

  2. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Peter S. Walmod

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Ypsilanti, A.R., Chedotal, A. (2014). ROUNDABOUT Receptors. In: Berezin, V., Walmod, P. (eds) Cell Adhesion Molecules. Advances in Neurobiology, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8090-7_7

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