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Protocadherins in Neurological Diseases

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Cell Adhesion Molecules

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 8))

Abstract

Cadherins were originally isolated as calcium-dependent cell adhesion molecules and are characterized by their cadherin motifs in the extracellular domain. In vertebrates, including humans, there are more than 100 different cadherin-related genes, which constitute the cadherin superfamily. The protocadherin (Pcdh) family comprises a large subgroup within the cadherin superfamily. The Pcdhs are divided into clustered and non-clustered Pcdhs, based on their genomic structure. Almost all the Pcdh genes are expressed widely in the brain and play important roles in brain development and in the regulation of brain function. This chapter presents an overview of Pcdh family members with regard to their functions, knockout mouse phenotypes, and association with neurological diseases and tumors.

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Acknowledgements

We thank Dr. Teruyoshi Hirayama for helpful comments.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. KOKORO-Biology group and JST-CREST, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Osaka, Suita, 565-0874, Japan

    Takahiro Hirabayashi Ph.D. & Takeshi Yagi Ph.D.

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  1. Takahiro Hirabayashi Ph.D.
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  2. Takeshi Yagi Ph.D.
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Correspondence to Takahiro Hirabayashi Ph.D. .

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Editors and Affiliations

  1. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Vladimir Berezin

  2. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Peter S. Walmod

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Hirabayashi, T., Yagi, T. (2014). Protocadherins in Neurological Diseases. In: Berezin, V., Walmod, P. (eds) Cell Adhesion Molecules. Advances in Neurobiology, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8090-7_13

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