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Stem Cell Therapy: From the Heart to the Periphery

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Stem Cells: Current Challenges and New Directions

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Peripheral artery disease remains a clinical challenge—together with coronary artery disease, it accounts for increased morbidity and mortality in the concerned patients. Therapeutic concepts are often limited because of underlying co-morbidities and generalised atherosclerosis. The search for new forms of intervention follows several directions with stem cell therapy or therapeutic angiogenesis being one of the most promising approaches. The following chapter should provide an overview on the significance of the disease and the limitations of currently applied procedures. The biological concept which is the driving force of improvement in this special clinical situation is presented, and a brief overview on the history of stem cell therapy for vascular regeneration is given. So far, regarding peripheral artery disease, this story is a story of success, and future clinical approaches will take into account new sources of stem cells beside bone marrow to successfully treat patients with the disease, even in palliative situations.

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Authors and Affiliations

  1. Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Diabeteszentrum, Georgstrasse 11, Bad Oeynhausen, D-32545, Germany

    Bernd Stratmann & Diethelm Tschoepe

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  1. Bernd Stratmann
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  2. Diethelm Tschoepe
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Correspondence to Bernd Stratmann .

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  1. Regenerative Medicine Program, Ottawa Hospital Research Institute Sprott Centre for Stem Cell Research, Ottawa, Ontario, Canada

    Kursad Turksen

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Stratmann, B., Tschoepe, D. (2013). Stem Cell Therapy: From the Heart to the Periphery. In: Turksen, K. (eds) Stem Cells: Current Challenges and New Directions. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8066-2_8

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