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Immunoregulatory Properties of Mesenchymal Stem Cells: In Vitro and In Vivo

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Stem Cells: Current Challenges and New Directions

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Over the last few years, because of their self-renewal capacity and multilineage differentiation potency, mesenchymal stem cells (MSCs) have been thought to have important therapeutic potential. MSCs are considered to be effective in immune system by suppressing maturation of DC and the functions of T cells, B cells, and natural killer (NK) cells, by inducing regulatory T (Treg) cells. Although target cell–MSC interactions may play important role, the MSC-mediated immunosuppression also mainly acts through the secretion of soluble molecules and cytokines that are induced or upregulated following interactions with immune cells. The majority of data on the immunomodulation of MSCs are in vitro, although several studies have been in vivo. Various animal models such as mouse, baboon, and rat have been used to evaluate in vivo MSC immunoregulatory properties related to alloreactive immunity in SC and organ transplantations, autoimmunity, or tumor immunity. Clinical studies with MSC have aimed to demonstrate promising results in treating patients with cancer, reducing the incidence of GVHD after BM transplantation, improving and treating amyotrophic lateral sclerosis, Crohn’s disease, metachromatic leukodystrophy, Hurler syndrome, rheumatoid arthritis, type 1 diabetes mellitus, lupus nephritis, and liver cirrhosis.

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  1. Department of Stem Cell, Stem Cell and Gene Therapies Research & Applied Center, Institute of Medical Sciences, Kocaeli University, Ummuttepe-Izmit, 41380, Kocaeli, Turkey

    Pinar Çetinalp Demircan Ph.D., Ayla Eker Sariboyaci Ph.D. & Erdal Karaoz Ph.D.

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  1. Pinar Çetinalp Demircan Ph.D.
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  2. Ayla Eker Sariboyaci Ph.D.
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  3. Erdal Karaoz Ph.D.
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Correspondence to Pinar Çetinalp Demircan Ph.D. .

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  1. Regenerative Medicine Program, Ottawa Hospital Research Institute Sprott Centre for Stem Cell Research, Ottawa, Ontario, Canada

    Kursad Turksen

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Demircan, P.Ç., Sariboyaci, A.E., Karaoz, E. (2013). Immunoregulatory Properties of Mesenchymal Stem Cells: In Vitro and In Vivo. In: Turksen, K. (eds) Stem Cells: Current Challenges and New Directions. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8066-2_3

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