Skip to main content

Enteral Diets and Parenteral Feedings with Different n-6/n-3 Ratios in Rats and Mice

  • Reference work entry
  • First Online:
Diet and Nutrition in Critical Care
  • 109 Accesses

Abstract

This chapter discusses animal studies in rats. N-3 polyunsaturated fatty acids (PUFAs) have been shown to suppress inflammation and regulate the immune response. These effects were reported with enteral diets administered during heart allotransplantation, sepsis, and intestinal damage. Additionally, n-3 PUFAs improve blood flow in the intestine. Moreover, animal studies reveal the importance of n-6/n-3 ratios of enteral diets in both short-term and long-term administration due to the influence on n-6/n-3 ratios in some tissues including the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

DHA:

Docosahexaenoic acid

EPA:

Eicosapentaenoic acid

PUFA:

Polyunsaturated fatty acid

RBC:

Red blood cell

References

  • Calder PC. N-3 fatty acids, inflammation, and immunity–relevance to postsurgical and critically ill patients. Lipids. 2004;39:1147–61.

    Article  CAS  PubMed  Google Scholar 

  • Grimm H, Tibell A, Norrlind B, Blecher C, Wilker S, Schwemmle K. Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. J Parenter Enteral Nutr. 1994;18:417–21.

    Article  CAS  Google Scholar 

  • Hurt RT, Garrison RN, Derhake BM, Matheson PJ. Fish oil increases blood flow in the ileum during chronic feeding in rats. Nutr Res. 2012;32:837–43.

    Article  CAS  PubMed  Google Scholar 

  • Inatomi O, Andoh A, Tsujikawa T, Fujiyama Y. N-3 fatty acid-rich diet effectively reduced early mucosal inflammation responses in trinitrobenzene sulfonic acid-induced enteritis. J JSMUFF. 2004;2:99–103.

    Google Scholar 

  • Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids. Br J Nutr. 2013;109:89–98.

    Article  CAS  PubMed  Google Scholar 

  • Palombo JD, Lydon EE, Chen PL, Bistrian BR. Fatty acid composition of lung, macrophage and surfactant phospholipids after short-term enteral feeding with n-3 lipids. Lipids. 1994;29:643–9.

    Article  CAS  PubMed  Google Scholar 

  • Tanmoy KD, Santinath G, Mahua G, Hemanta K, Pubali D. Comparative study of gastrointestinal absorption of EPA & DHA rich fish oil from nano and conventional emulsion formulation in rats. Food Res Int. 2012;49:72–9.

    Article  Google Scholar 

  • Tsutsumi R, Horikawa YT, Kume K, Tanaka K, Kasai A, Kadota T, Tsutsumi YM. Whey peptide-based formulas with ω-3 fatty acids are protective in LPS-Mediated sepsis. JPEN J Parenter Enteral Nutr. 2014; in print.

    Google Scholar 

  • Ueki A. Alzheimer-type dementia and nutrition. Medical Science Digest. 2004;30:224–227.

    Google Scholar 

  • Watanabe N, Onuma K, Fujimoto K, Miyake S, Nakamura T. Long-term effect of an enteral diet with a different n-6/n-3 ratio on fatty acid composition and blood parameters in rats. J Oleo Sci. 2011;60:109–15.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nakamichi Watanabe .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this entry

Cite this entry

Watanabe, N. (2015). Enteral Diets and Parenteral Feedings with Different n-6/n-3 Ratios in Rats and Mice. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Diet and Nutrition in Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7836-2_154

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7836-2_154

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7837-9

  • Online ISBN: 978-1-4614-7836-2

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics