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Functional Neurosurgery with MR-Guided HIFU

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Intraoperative Imaging and Image-Guided Therapy

Abstract

Transcranial magnetic resonance imaging-guided focused ultrasound (TcMRgFUS) has recently entered clinical trials for functional neurosurgery. This novel methodology is noninvasive and does not use radioactivity or ionizing radiation. TcMRgFUS integrates advanced MR image acquisition modes for precise anatomical information, local temperature maps, and tissue stiffness, with complex computer-controlled large phased array ultrasound transducers. It provides treatment monitoring and closed-loop therapy control by precisely focusing ultrasound energy to a desired target deep inside the brain while leaving collateral structures unaltered. As a noninvasive alternative to traditional neurosurgery, TcMRgFUS has the potential of treating a variety of chronic therapy-resistant neurological diseases, such as neuropathic pain, movement disorders, tinnitus, and epilepsy, which makes it certainly attractive.

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Author information

Authors and Affiliations

  1. MR-Center, University Children’s Hospital Zürich, Zürich, Switzerland

    Ernst Martin-Fiori MD & Beat Werner MSc

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  1. Ernst Martin-Fiori MD
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  2. Beat Werner MSc
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Correspondence to Ernst Martin-Fiori MD .

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Editors and Affiliations

  1. National Center for Image Guided Therapy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Ferenc A. Jolesz

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Martin-Fiori, E., Werner, B. (2014). Functional Neurosurgery with MR-Guided HIFU. In: Jolesz, F. (eds) Intraoperative Imaging and Image-Guided Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7657-3_45

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  • DOI: https://doi.org/10.1007/978-1-4614-7657-3_45

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