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Pancreaticoduodenectomy Using Perioperative Zymogen Protein C to Help Prevent Blood Clotting: A Trilogy on Increased Patient Safety

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Oxygen Transport to Tissue XXXV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 789))

Abstract

The blood clotting mechanism is a very important and complex physiologic process. Blood flow must be continuous through the blood vessels to provide essential oxygen and nutrients to the cells of the body. Dr. Melvin H. Knisely (Honorary First President of ISOTT, 1973) named and pioneered research in blood sludging and clotting which led to his nomination for the Nobel Prize by Dr. August Krogh in 1948. Abnormal clotting is a pathological state that can inhibit and prevent normal blood flow, leading to reduced oxygen transport to tissue from the microcirculation. It can result in the death of cells and tissues, including entire organs as well as the patient. Blood clotting and sludging are common occurrences during and after invasive surgery; thus, it is imperative to find safe procedures to reduce or prevent these deadly phenomena. All anticoagulants used today, for clot prevention and dissolution, can cause excessive bleeding that can lead to enormous medical expense to provide control, otherwise causing patient death. Protein C is a natural protein and is the pivotal anticoagulant in the blood. Due to the mechanism of converting the zymogen protein C (ZPC) to active protein C (APC), only when and where it is needed, and their respective half-lives in the body, the natural anticoagulant, antithrombotic characteristics of APC can be utilized without causing bleeds.

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Acknowledgments 

The authors would like to express their appreciation to E. Eileen Thiessen for the preparation of the PowerPoint slide presentation and the production of this chapter.

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Authors and Affiliations

  1. Synthesizer, Inc., 2773 Westminster Road, Ellicott City, MD, 21043, USA

    Duane F. Bruley

  2. Department of Surgery, University of Colorado, Aurora, CO, 80045, USA

    Richard D. Schulick

  3. Anticoagulation Management Service, Division of Hematology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA

    Michael B. Streiff

Authors
  1. Duane F. Bruley
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  2. Richard D. Schulick
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  3. Michael B. Streiff
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Corresponding author

Correspondence to Duane F. Bruley .

Editor information

Editors and Affiliations

  1. Department of Electrical Engineering and iMinds Future Health Department, KU Leuven, Leuven, Belgium

    Sabine Van Huffel  & Alexander Caicedo  & 

  2. Neonatal Intensive Care Unit KU Leuven, University Hospitals, Leuven, Belgium

    Gunnar Naulaers

  3. Synthesizer, Inc., Ellicott City, MD, USA

    Duane F. Bruley

  4. Microvascular Measurements, Lorenzen, Italy

    David K. Harrison

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Bruley, D.F., Schulick, R.D., Streiff, M.B. (2013). Pancreaticoduodenectomy Using Perioperative Zymogen Protein C to Help Prevent Blood Clotting: A Trilogy on Increased Patient Safety. In: Van Huffel, S., Naulaers, G., Caicedo, A., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, vol 789. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7411-1_40

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