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Hypoxia, Lactate Accumulation, and Acidosis: Siblings or Accomplices Driving Tumor Progression and Resistance to Therapy?

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Oxygen Transport to Tissue XXXV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 789))

Abstract

This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible “targeted” therapeutic interventions.

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Author information

Authors and Affiliations

  1. Department of Radiooncology and Radiotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

    Arnulf Mayer & Peter Vaupel

Authors
  1. Arnulf Mayer
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  2. Peter Vaupel
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Corresponding author

Correspondence to Arnulf Mayer .

Editor information

Editors and Affiliations

  1. Department of Electrical Engineering and iMinds Future Health Department, KU Leuven, Leuven, Belgium

    Sabine Van Huffel  & Alexander Caicedo  & 

  2. Neonatal Intensive Care Unit KU Leuven, University Hospitals, Leuven, Belgium

    Gunnar Naulaers

  3. Synthesizer, Inc., Ellicott City, MD, USA

    Duane F. Bruley

  4. Microvascular Measurements, Lorenzen, Italy

    David K. Harrison

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Mayer, A., Vaupel, P. (2013). Hypoxia, Lactate Accumulation, and Acidosis: Siblings or Accomplices Driving Tumor Progression and Resistance to Therapy?. In: Van Huffel, S., Naulaers, G., Caicedo, A., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, vol 789. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7411-1_28

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