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Skin Adnexal Tumours: A Large Spectrum of Clinic-Pathological Lesions

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Skin Cancer

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Skin adnexal neoplasms comprise a wide spectrum of more than 80 benign and malignant tumours, exhibiting morphological differentiation towards pilosebaceous unit, eccrine and apocrine glands. In addition more than one line of differentiation in this neoplasm could be observed. These tumours generally exhibit a benign behaviour, but malignant histotypes also exist. Clinical diagnosis of specific entity and of their potential malignancy is quite impossible. Thus, the diagnosis always requires surgical excision of skin lesion, and histological features at haematoxylin and eosin-stained sections are considered generally adequate for the correct classification of skin adnexal tumours. The use of histochemical and immunohistochemical stains could further aid in this purpose. Finally, they are usually encountered as single, sporadic tumours, but they may also occasionally be multiple and hereditary, heralding complex genetic syndromes that comprise visceral cancers.

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Author information

Authors and Affiliations

  1. Pathology Unit, National Institute of Tumours Fondazione “G. Pascale”, Naples, Italy

    Renato Franco, Federica Zito Marino, Anna Maria Anniciello & Gerardo Botti

  2. Pathology Unit, Paediatric Hospital Santobono-Pausilipon, Naples, Italy

    Maria Elena Errico

  3. Department of Biochemistry and Biophysics, Second University of Naples, Via S.M. Costantinopoli, 16, Naples, 80138, Italy

    Michele Caraglia MD, PhD & Anna Grimaldi

Authors
  1. Renato Franco
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  2. Maria Elena Errico
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  3. Federica Zito Marino
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  4. Anna Maria Anniciello
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  5. Gerardo Botti
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  6. Michele Caraglia MD, PhD
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  7. Anna Grimaldi
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Corresponding author

Correspondence to Michele Caraglia MD, PhD .

Editor information

Editors and Affiliations

  1. and Pharmaceutical Sciences and Technologies, Second University of Naples Department of Environmental, Biological, Naples, Italy

    Alfonso Baldi

  2. Department of Dermatology, Pius Hospital de Valls, Valls, Tarragona, Spain

    Paola Pasquali

  3. S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy

    Enrico P Spugnini

Glossary

APC

Adenomatous polyposis coli

BCC

Basal-cell carcinoma

BHDS

Birt–Hogg–Dube’ syndrome

CAT

Cutaneous appendage tumors

CHRPE

Congenital hypertrophy of the retinal pigment epithelium

CS

Cowden syndrome

CSG

Cutaneous sweat gland

CSGT

Cutaneous sweat gland tumours

FAP

Familial adenomatous polyposis

FLCN

Folliculin

GS

Gardner syndrome

H&E

Haematoxylin and eosin

MFT

Multiple familial tricoepithelioma

MLG

Mammary-like glands

MTS

Muir–Torre syndrome

NSJ

Nevus sebaceous of Jadassohn

PTC

Proliferating trichilemmal cyst

PTEN

Phosphatase and TENsin

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Franco, R. et al. (2014). Skin Adnexal Tumours: A Large Spectrum of Clinic-Pathological Lesions. In: Baldi, A., Pasquali, P., Spugnini, E. (eds) Skin Cancer. Current Clinical Pathology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7357-2_6

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