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Inherited Contributions to Melanoma Risk

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Melanoma

Abstract

While exposure to ultraviolet radiation (UVR) is a significant factor contributing to the risk of developing cutaneous malignant melanoma (CMM), genetics plays a significant role in both the context of high-risk melanoma families as well as the general population. While two high-risk melanoma susceptibility genes, CDKN2A and CDK4, have been known for decades, technological advances in recent years have enabled the recent identification of numerous genes and/or genetic loci mediating risk. A review of this progress, including rare high-penetrance gene mutations involved in familial melanoma as well as more common population variants of intermediate to low effect, is summarized in this chapter.

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Author information

Authors and Affiliations

  1. Laboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Kevin M. Brown

  2. Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

    Stuart MacGregor & Matthew H. Law

Authors
  1. Kevin M. Brown
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  2. Stuart MacGregor
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  3. Matthew H. Law
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Corresponding author

Correspondence to Kevin M. Brown .

Editor information

Editors and Affiliations

  1. Harvard/MGH Cutaneous Biology Research C Massachusetts General Hospital, Boston, Massachusetts, USA

    David E. Fisher

  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Boris C. Bastian

Section Editor information

  1. Department of Dermatology, Harvard/MGH Cutaneous Biology Research Center, and Melanoma Program, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    David E. Fisher M.D.

  2. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    Nick Hayward

  3. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    David C. Whiteman

  4. Henri and Belinda Termeer Center for Targeted Therapies, MGH Cancer Center, Boston, MA, USA

    Keith T. Flaherty

  5. Framingham, MA, USA

    F. Stephen Hodi M.D.

  6. Department of Medicine, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA, USA

    F. Stephen Hodi M.D.

  7. Auburndale, MA, USA

    Hensin Tsao

  8. Harvard-MIT Health Sciences and Technology, Cambridge, MA, USA

    Hensin Tsao

  9. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Glenn Merlino Ph.D.

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Brown, K.M., MacGregor, S., Law, M.H. (2018). Inherited Contributions to Melanoma Risk. In: Fisher, D., Bastian, B. (eds) Melanoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7322-0_31-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7322-0_31-1

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  • Print ISBN: 978-1-4614-7322-0

  • Online ISBN: 978-1-4614-7322-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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