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The Hodgkin-Huxley model is a mathematical model of current flow through ion-selective channels in neural membrane. Hodgkin and Huxley were able to describe the time behavior of the intracellular membrane potential and the currents through potassium (K) and sodium (Na) channels with simple first-order ordinary differential equations. This was done using parameters fitted from their voltage clamp Technique measurements on the giant axon of the squid. With this model, they quantitatively described the generation of action potentials by current injection and observable behavior such as the refractory period and the anode break phenomenon. With other sets of parameters, the Hodgkin-Huxley model has been used to describe many other types of voltage-dependent ion channels and has become a standard technique in compartmental modeling of neurons.
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In a series of five classic papers published in 1952,...
References
Beeman D (2008) Lectures on computational neuroscience: the Hodgkin-Huxley model. http://www.genesis-sim.org/GENESIS/UGTD/Tutorials/cnslecs/cnslecs.html
Bower JM (1995) Reverse engineering the nervous system: an in vivo, in vitro, and in computo approach to understanding the mammalian olfactory system. In: Zornetzer SF, Davis JL, Lau C (eds) An introduction to neural and electronic networks, 2nd edn. Academic, New York, pp 3–28
Bower JM, Beeman D (1998) The book of GENESIS: exploring realistic neural models with the GEneral NEural SImulation System, 2nd edn. Springer, New York
Bower JM, Beeman D (2003) The book of GENESIS: exploring realistic neural models with the GEneral NEural SImulation System, free internet edition. http://www.genesis-sim.org/GENESIS/iBoG/iBoG.pdf
Caterall WA (2012) Voltage-gated sodium channels at 60: structure, function and pathophysiology. J Physiol 590:2577–2589
Cornelis H, Coop A, Bower JM (2012) A federated design for a neurobiological simulation engine: the CBI federated software architecture. PLoS ONE 7(1):e28956. doi:10.1371/journal.pone.0028956
Hodgkin A, Huxley A (1952a) Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J Physiol 116:449–472
Hodgkin A, Huxley A (1952b) The components of membrane conductance in the giant axon of Loligo. J Physiol 116:473–496
Hodgkin A, Huxley A (1952c) The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J Physiol 116:497–506
Hodgkin A, Huxley A (1952d) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500–544
Hodgkin A, Huxley A, Katz B (1952) Measurement of current–voltage relations in the membrane of the giant axon of Loligo. J Physiol 116:424–448
Kandel ER, Schwartz JH, Jessell TM (2000) Principles of neural science. McGraw-Hill, New York, pp 126–134
Nelson M, Rinzel J (1998) The Hodgkin-Huxley model. In: Bower J, Beeman D (eds) The book of GENESIS: exploring realistic neural models with the GEneral NEural SImulation System, 2nd edn. Springer, New York, pp 29–49
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Beeman, D. (2014). Hodgkin-Huxley Model. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_127-3
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_127-3
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