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Dietary Fats as Mediators of Obesity, Inflammation, and Colon Cancer

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

Obesity and associated low-grade inflammation are clearly risk factors for development of diabetes, cardiovascular disease, and cancer; however, the mechanisms and pathways by which obesity and inflammation lead to these disorders are not clearly defined. Since obesity is largely determined by levels of energy expenditure as well as quantities and composition of consumed nutrients, especially fats and carbohydrates, the question exists as to whether obesity and/or dietary components contribute directly to development of inflammation and/or associated comorbidities including diabetes, cancer, and cardiovascular disease. In this chapter, we examine the evidence supporting a role for dietary fats in the development of inflammation and intestinal tumorigenesis. We also compare different fats and different diets for their ability to promote or prevent intestinal tumorigenesis and explore possible mechanisms of action. These considerations are important for the potential prevention and control of intestinal cancer, since overall diet and specific dietary components are modifiable risk factors and increasing numbers of dietary and pharmacologic interventions are becoming available to control both inflammatory and carcinogenic processes.

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Authors and Affiliations

  1. Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106-4915, USA

    Stephanie K. Doerner Ph.D.

  2. Center for Science, Health and Society, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106-4971, USA

    Nathan A. Berger M.D.

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  1. Stephanie K. Doerner Ph.D.
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  2. Nathan A. Berger M.D.
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Correspondence to Nathan A. Berger M.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Doerner, S.K., Berger, N.A. (2013). Dietary Fats as Mediators of Obesity, Inflammation, and Colon Cancer. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_5

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