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Methylation

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Cancer Therapeutic Targets

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Abstract

Alterations of DNA methylation patterns and other epigenetic changes, such as covalent histone posttranscriptional modifications (methylation, acetylation, phosphorylation, ubiquitination, sumoylation), chromatin-remodeling processes, and more, are well-known phenomena observed in various disease processes including cancer. In fact, global DNA hypomethylation and promoter hypermethylation are promising biomarkers for cancer.

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References

  • Bhutani N, Burns DM, Blau HM. DNA demethylation dynamics. Cell. 2011;146(6):866–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, International Vidaza High-Risk MDS Survival Study Group, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009;10(3):223–32. AZA-001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fernandez AF, Assenov Y, Martin-Subero JI, et al. A DNA methylation fingerprint of 1628 human samples. Genome Res. 2012;22(2):407–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heichman KA, Warren JD. DNA methylation biomarkers and their utility for solid cancer diagnostics. Clin Chem Lab Med. 2012;50(10):1707–21.

    Article  CAS  PubMed  Google Scholar 

  • Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet. 2012;13(10):679–92.

    Article  CAS  PubMed  Google Scholar 

  • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006;106(8):1794–803. DCA phase III.

    Article  CAS  PubMed  Google Scholar 

  • Laird PW. Principles and challenges of genome-wide DNA methylation analysis. Nat Rev Genet. 2010;11(3):191–203.

    Article  CAS  PubMed  Google Scholar 

  • Miranda TB, Jones PA. DNA methylation: the nuts and bolts of repression. J Cell Physiol. 2007;213(2):384–90.

    Article  CAS  PubMed  Google Scholar 

  • Shanmuganathan R, Basheer NB, Amirthalingam L, et al. Conventional and nanotechniques for DNA methylation profiling. J Mol Diagn. 2013;15(1):17–26.

    Article  CAS  PubMed  Google Scholar 

  • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol. 2002;20(10):2429–40. CLAGB 9221.

    Article  CAS  PubMed  Google Scholar 

  • Toraño EG, Petrus S, Fernandez AF, et al. Global DNA hypomethylation in cancer: review of validated methods and clinical significance. Clin Chem Lab Med. 2012;50(10):1733–42.

    Article  PubMed  Google Scholar 

  • Zhou L, Cheng X, Connolly BA, et al. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol. 2002;321:591–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 12C101, Bethesda, MD, 20892, USA

    Helen Gharwan & Manisha Bhutani

Authors
  1. Helen Gharwan
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  2. Manisha Bhutani
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Corresponding author

Correspondence to Helen Gharwan .

Editor information

Editors and Affiliations

  1. Georgetown University Div. Hematology & Oncology, Washington, District of Columbia, USA

    John L. Marshall

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Gharwan, H., Bhutani, M. (2014). Methylation. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6613-0_67-3

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  • DOI: https://doi.org/10.1007/978-1-4614-6613-0_67-3

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6613-0

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