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Rhabdomyolysis and Myoglobinuria

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Neuromuscular Disorders in Clinical Practice

Abstract

Rhabdomyolysis and myoglobinuria are commonly encountered in clinical practice. This chapter reviews the present state of knowledge of the clinical and biochemical diagnosis of rhabdomyolysis, its pathophysiology, classification, provocative factors and associated diseases, and the management of patients including diagnostic and therapeutic guidelines.

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References

  1. Baldea A, Luchette FA, Shapiro ML. Rhabdomyolysis in the intensive care unit. J Intensive Care Med. 2012;27:335–42.

    Article  PubMed  Google Scholar 

  2. Billis AG. Acute renal failure after a meal of quail. Lancet. 1971;298:702.

    Article  Google Scholar 

  3. Corti M, Pozzi C, Pozzoni P, Tentori F. Rhabdomyolysis as a complication of Parkinson’s disease. G Ital Nefrol. 2002;19:13–7.

    PubMed  Google Scholar 

  4. Ikebe S, Harada T, Hashimoto T, et al. Prevention and treatment of malignant syndrome in Parkinson’s disease: a consensus statement of the malignant syndrome research group. Parkinsonism Relat Disord. 2003;9 Suppl 1:S47–9.

    Article  PubMed  Google Scholar 

  5. Gabreels FJM, Poels PJE, Verrips A. Rhabdomyolysis and myoglobinuria. In: Katirji B, Kaminski HJ, Preston DC, Ruff RL, Shapiro BE, editors. Neuromuscular disorders in clinical practice. Boston: Butterworth Heinemann; 2001. p. 1319–33.

    Google Scholar 

  6. Bowden DH, Eraser D, Jackson SH, Walker NE. Acute recurrent rhabdomyolysis (paroxysmal myohaemoglobinuria). Medicine. 1956;35:335–53.

    Article  PubMed  CAS  Google Scholar 

  7. Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine. 1982;3:141–52.

    Google Scholar 

  8. Busch HFM, Jennekens FGI, Scholte HR, editors. Mitochondria and muscular diseases: proceedings of a symposium held at the Erasmus University, Rotterdam; 1981, 11th–12th Dec 1980.

    Google Scholar 

  9. Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem. 1987;56:395–433.

    Article  PubMed  CAS  Google Scholar 

  10. Knochel JP. Rhabdomyolysis and myoglobinuria. Annu Rev Med. 1982;33:435–43.

    Article  PubMed  CAS  Google Scholar 

  11. Jackson MJ, Jones DA, Edwards RH. Experimental skeletal muscle damage: the nature of the calcium-activated degenerative processes. Eur J Clin Invest. 1984;14:369–74.

    Article  PubMed  CAS  Google Scholar 

  12. Blumbergs PC, Thompson PD, Warren J. Rhabdomyolysis: a review. Muscle Nerve. 2002;25:332–47.

    Article  PubMed  CAS  Google Scholar 

  13. Koskelo P, Kekki M, Wager O. Kinetic behaviour of 131-I-labelled myoglobin in human beings. Clin Chim Acta. 1967;17:339–47.

    Article  PubMed  CAS  Google Scholar 

  14. Adams EC. Differentiation of myoglobin and hemoglobin in biological fluids. Ann Clin Lab Sci. 1980;10:493–9.

    PubMed  CAS  Google Scholar 

  15. Moss DW, Henderson DR, Kachmar JF. Enzymes. In: Tietz NW, editor. Textbook of clinical chemistry. Philadelphia: WB Saunders; 1986. p. 698–700.

    Google Scholar 

  16. Kato K, Mokuno K. Distribution of immunoreactive carbonic anhydrase III in various human tissues determined by a sensitive enzyme immunoassay method. Clin Chim Acta. 1984;141:169–77.

    Article  PubMed  CAS  Google Scholar 

  17. Syrjala H, Vuori J, Huttunen K, Vaananen HK. Carbonic anhydrase III as a serum marker for diagnosis of rhabdomyolysis. Clin Chem. 1990;36:696.

    PubMed  CAS  Google Scholar 

  18. Akmal M, Goldstein DA, Telfer N, Wilkinson E, Massry SG. Resolution of muscle calcification in rhabdomyolysis and acute renal failure. Ann Intern Med. 1978;89:928–30.

    Article  PubMed  CAS  Google Scholar 

  19. Llach F, Felsenfeld AJ, Haussler MR. The pathophysiology of altered calcium metabolism in rhabdomyolysis-induced acute renal failure. Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol. N Engl J Med. 1981;305:117–23.

    Article  PubMed  CAS  Google Scholar 

  20. Knochel JP, Barcenas C, Cotton JR, Fuller TJ, Haller R, Carter NW. Hypophosphatemia and rhabdomyolysis. J Clin Invest. 1978;62:1240–6.

    Article  PubMed  CAS  Google Scholar 

  21. Ruitenbeek W, Poels PJ, Turnbull DM, Garavaglia B, Chalmers RA, Taylor RW, et al. Rhabdomyolysis and acute encephalopathy in late onset medium chain acyl-CoA dehydrogenase deficiency. J Neurol Neurosurg Psychiatry. 1995;58:209–14.

    Article  PubMed  CAS  Google Scholar 

  22. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine. 2005;84:377–85.

    Article  PubMed  Google Scholar 

  23. Martin DW, Watts HD, Smith LH. Rhabdomyolysis-medical staff conference, University of California, San Francisco. West J Med. 1976;125:298–304.

    Google Scholar 

  24. Honda N. Acute renal failure and rhabdomyolysis. Kidney Int. 1983;23:888–98.

    Article  PubMed  CAS  Google Scholar 

  25. Braun SR, Weiss FR, Keller AI, Ciccone JR, Preuss HG. Evaluation of the renal toxicity of heme proteins and their derivatives: a role in the genesis of acute tubule necrosis. J Exp Med. 1970;131:443–60.

    Article  PubMed  CAS  Google Scholar 

  26. Oken DE. Modern concepts of the role of nephrotoxic agents in the pathogenesis of acute renal failure. Prog Biochem Pharmacol. 1972;7:219–47.

    PubMed  CAS  Google Scholar 

  27. Stein JH, Lifschitz MD, Barnes LD. Current concepts on the pathophysiology of acute renal failure. Am J Physiol. 1978;234:171–81.

    Google Scholar 

  28. Tonin P, Lewis P, Servidei S, DiMauro S. Metabolic causes of myoglobinuria. Ann Neurol. 1990;27:181–5.

    Article  PubMed  CAS  Google Scholar 

  29. Sieb J, Penn AS. Myoglobinuria. In: Engel AG, Franzini-Armstrong C, editors. Myology. 3rd ed. New York: McGraw-Hill Inc.; 2004. p. 1677–92.

    Google Scholar 

  30. Meyer-Betz E. Beobachtungen an einem eigenartigen mit Muskellähmungen verbunden Fall von Hämoglobinurie. Dtsch Arch Klin Med. 1911;101:85.

    Google Scholar 

  31. Ruff RL. Elevated intracellular Ca2+ and myofibrillar Ca2+ sensitivity cause iodoacetate-induced muscle contractures. J Appl Physiol. 1996;81:1230–9.

    PubMed  CAS  Google Scholar 

  32. Ruff RL, Weissman J. Iodoacetate-induced contracture in rat skeletal muscle: possible role of ADP. Am J Physiol. 1991;261:C828–36.

    PubMed  CAS  Google Scholar 

  33. Karlsson J, Saltin B. Lactate, ATP, and CP in working muscles during exhaustive exercise in man. J Appl Physiol. 1970;29:596–602.

    PubMed  CAS  Google Scholar 

  34. Sinkeler SP, Joosten EM, Wevers RA, Oei TL, Jacobs AE, Veerkamp JH, et al. Myoadenylate deaminase deficiency: a clinical, genetic, and biochemical study in nine families. Muscle Nerve. 1988;11:312–7.

    Article  PubMed  CAS  Google Scholar 

  35. Schmid R, Mahler R. Chronic progressive myopathy with myoglobinuria: demonstration of a glycogenolytic defect in the muscle. J Clin Invest. 1959;38:2044–58.

    Article  PubMed  CAS  Google Scholar 

  36. Braakhekke JP, de Bruin MI, Stegeman DF, Wevers RA, Binkhorst RA, Joosten EM. The second wind phenomenon in McArdle’s disease. Brain. 1986;109:1087–101.

    Article  PubMed  Google Scholar 

  37. Abarbanel JM, Bashan N, Potashnik R, Osimani A, Moses SW, Herishanu Y. Adult muscle phosphorylase “b” kinase deficiency. Neurology. 1986;36:560–2.

    Article  PubMed  CAS  Google Scholar 

  38. DiMauro S, Tsujino S. Nonlysosomal glycogenoses. In: Engel AG, Franzini-Armstrong C, editors. Myology. 2nd ed. New York: McGraw-Hill Inc.; 1994. p. 1554–76.

    Google Scholar 

  39. DiMauro S. Metabolic myopathies. In: Vinken PJ, Bruyn GW, ­editors. Handbook of clinical neurology. Amsterdam: North-Holland Publishing Company; 1979. p. 175–234.

    Google Scholar 

  40. DiMauro S, Dalakas M, Miranda AF. Phosphoglycerate kinase deficiency: another cause of recurrent myoglobinuria. Ann Neurol. 1983;13:11–9.

    Article  PubMed  CAS  Google Scholar 

  41. DiMauro S, Miranda AF, Olarte M, Friedman R, Hays AP. Muscle phosphoglycerate mutase deficiency. Neurology. 1982;32:584–91.

    Article  PubMed  CAS  Google Scholar 

  42. DiMauro S, DiMauro PM. Muscle carnitine palmitoyltransferase deficiency and myoglobinuria. Science. 1973;182:929–31.

    Article  PubMed  CAS  Google Scholar 

  43. Linderholm H, Muller R, Ringqvist T, Sornas R. Hereditary abnormal muscle metabolism with hyperkinetic circulation during exercise. Acta Med Scand. 1969;185:153–66.

    Article  PubMed  CAS  Google Scholar 

  44. DiDonato S. Disorders of lipid metabolism affecting skeletal muscle: carnitine deficiency syndrome, defects in catabolic pathway, and chanarin disease. In: Engel AG, Franzini-Armstrong C, editors. Myology. 2nd ed. New York: McGraw-Hill Inc.; 1994. p. 1587–609.

    Google Scholar 

  45. Prockop LD, Engel WK, Shug AL. Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy. Neurology. 1983;33:1629–31.

    Article  PubMed  CAS  Google Scholar 

  46. Carrier HN, Berthillier G. Carnitine levels in normal children and adults and in patients with diseases muscle. Muscle Nerve. 1980;3:326–34.

    Article  PubMed  CAS  Google Scholar 

  47. Engel AG, Rebouche CJ. Pathogenetic mechanisms in human carnitine deficiency syndromes. In: Schotland DL, editor. Disorders of the motor unit. New York: Wiley; 1982. p. 643–56.

    Google Scholar 

  48. Stanley CA. New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency. Adv Pediatr. 1987;34:59–88.

    PubMed  CAS  Google Scholar 

  49. Tyni T, Pihko H. Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Acta Paediatr. 1999;88:237–45.

    Article  PubMed  CAS  Google Scholar 

  50. Tein I, De Vivo DC, Hale DE, Clarke JT, Zinman H, Laxer R, et al. Short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency in muscle: a new cause for recurrent myoglobinuria and encephalopathy. Ann Neurol. 1991;30:415–9.

    Article  PubMed  CAS  Google Scholar 

  51. Bruno C, Dimauro S. Lipid storage myopathies. Curr Opin Neurol. 2008;21:601–6.

    Article  PubMed  CAS  Google Scholar 

  52. Martin Du Pan RC, Morris MA, Favre H, Junod A, Pizzolato GP, Bottani A. Mitochondrial anomalies in a Swiss family with ­autosomal dominant myoglobinuria. Am J Med Genet. 1997;69:365–9.

    Article  PubMed  CAS  Google Scholar 

  53. Fishbein WN, Armbrustmacher VW, Griffin JL. Myoadenylate deaminase deficiency. Inherited and acquired forms. Biochem Med. 1985;33:158–69.

    Article  PubMed  CAS  Google Scholar 

  54. Kelemen J, Rice DR, Bradley WG, Munsat TL, DiMauro S, Hogan EL. Familial myoadenylate deaminase deficiency and exertional myalgia. Neurology. 1982;32:857–63.

    Article  PubMed  CAS  Google Scholar 

  55. Shumate JB, Katnik R, Ruiz M, Kaiser K, Frieden C, Brooke MH, et al. Myoadenylate deaminase deficiency. Muscle Nerve. 1979;2:213–6.

    Article  PubMed  CAS  Google Scholar 

  56. Engel AG, Potter CS, Rosevaer JW. Nucleotides and adenosine monophosphate deaminase activity of muscle in primary hypokalemic periodic paralysis. Nature. 1964;202:670–2.

    Article  PubMed  CAS  Google Scholar 

  57. Kar NC, Pearson CM. Muscle adenylate deaminase deficiency. Report of six new cases. Arch Neurol. 1981;38:279–81.

    Article  PubMed  CAS  Google Scholar 

  58. Gertler PA, Jacobs RP. Myoadenylate deaminase deficiency in a patient with progressive systemic sclerosis. Arthritis Rheum. 1984;27:586–90.

    Article  PubMed  CAS  Google Scholar 

  59. Sinkeler SP, Daanen HA, Wevers RA, Oei TL, Joosten EM, Binkhorst RA. The relation between blood lactate and ammonia in ischemic handgrip exercise. Muscle Nerve. 1985;8:523–7.

    Article  PubMed  CAS  Google Scholar 

  60. Verzijl HT, van Engelen BG, Luyten JA, Steenbergen GC, van den Heuvel LP, ter Laak HJ, et al. Genetic characteristics of myoadenylate deaminase deficiency. Ann Neurol. 1998;44:140–3.

    Article  PubMed  CAS  Google Scholar 

  61. Ohno K, Tanaka M, Sahashi K, Ibi T, Sato W, Yamamoto T, et al. Mitochondrial DNA deletions in inherited recurrent myoglobinuria. Ann Neurol. 1991;29:364–9.

    Article  PubMed  CAS  Google Scholar 

  62. Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW. Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. Muscle Nerve. 2000;23:90–7.

    Article  PubMed  CAS  Google Scholar 

  63. Joffe M, Savage N, Silove M. The biochemistry of malignant ­hyperthermia: recent concepts. Int J Biochem. 1992;24:387–98.

    Article  PubMed  CAS  Google Scholar 

  64. Rosenberg H, Sambuughin N, Dirksen R. Malignant hyperthermia susceptibility. In: Pagon RA, Bird TD, Dolan CR, Stephens K, ­editors. GeneReviews [Internet]. Seattle: University of Washington; 1993–2003 Dec 19. Updated 19 Jan 2010.

    Google Scholar 

  65. Kelemen J, Slonim A, Hubay M, Sreter FA. Ambulatory malignant hyperthermia syndrome: successful treatment with dantrolene sodium. Neurology. 1986;36 suppl 1suppl 1:240.

    Google Scholar 

  66. Guze BH, Baxter Jr LR. Current concepts. Neuroleptic malignant syndrome. N Engl J Med. 1985;313:163–6.

    Article  PubMed  CAS  Google Scholar 

  67. Goldberg LI. Monoamine oxidase inhibitors: adverse reaction and possible mechanisms. JAMA. 1964;190:456–62.

    Article  PubMed  CAS  Google Scholar 

  68. Behan WM, Bakheit AM, Behan PO, More IA. The muscle findings in the neuroleptic malignant syndrome associated with lysergic acid diethylamide. J Neurol Neurosurg Psychiatry. 1991;54:741–3.

    Article  PubMed  CAS  Google Scholar 

  69. Pariente EA, Nouel O, Bernuau J, Fraisse F, Degott C, Rueff B. [Acute rhabdomyolysis in alcoholic patients] Rhabdomyolyse aigue chez des malades alcooliques. Presse Med. 1983;12:339–43.

    PubMed  CAS  Google Scholar 

  70. Song SK, Rubin E. Ethanol produces muscle damage in human ­volunteers. Science. 1972;175:327–8.

    Article  PubMed  CAS  Google Scholar 

  71. Rubenstein AE, Wainapel SF. Acute hypokalemic myopathy in alcoholism. A clinical entity. Arch Neurol. 1977;34:553–5.

    Article  PubMed  CAS  Google Scholar 

  72. Hed R, Lundmark C, Fahlgren H, Orrel S. Acute muscular syndrome in alcoholism. Acta Med Scand. 1962;171:585.

    Article  PubMed  CAS  Google Scholar 

  73. Seneviratne BI. Acute cardiomyopathy with rhabdomyolysis in chronic alcoholism. Br Med J. 1975;4:378–80.

    Article  PubMed  CAS  Google Scholar 

  74. Victor M, Sieb JP. Myopathies due to drugs, toxins and nutritional deficiency. In: Engel AG, Franzini-Armstrong C, editors. Myology. 2nd ed. New York: McGraw-Hill Inc.; 1994. p. 1697–725.

    Google Scholar 

  75. Martin F, Ward K, Slavin G, Levi J, Peters TJ. Alcoholic skeletal myopathy, a clinical and pathological study. Q J Med. 1985;55:233–51.

    PubMed  CAS  Google Scholar 

  76. Ori Y, Korzets A, Gruzman C, Chagnac A, Zevin D, Weinstein T, et al. Postoperative rhabdomyolysis in patients with end-stage renal failure. Am J Kidney Dis. 1998;31:539–44.

    Article  PubMed  CAS  Google Scholar 

  77. Duflo F, Allaouchiche B, Mathon L, Chassard D. Bilateral anterior tibial compartment syndrome from prolonged surgery in the lithotomy position. Syndrome bilateral des loges tibiales anterieures apres chirurgie prolongee en position de lithotomie. Ann Fr Anesth Reanim. 1999;18:779–82.

    Article  PubMed  CAS  Google Scholar 

  78. Uratsuji Y, Ijichi K, Irie J, Sagata K, Nijima K, Kitamura S. Rhabdomyolysis after abdominal surgery in the hyperlordotic position enforced by pneumatic support. Anesthesiology. 1999;91:310–2.

    Article  PubMed  CAS  Google Scholar 

  79. Gabrielli A, Caruso L. Postoperative acute renal failure secondary to rhabdomyolysis from exaggerated lithotomy position [clinical conference]. J Clin Anesth. 1999;11:257–63.

    Article  PubMed  CAS  Google Scholar 

  80. de Gans J, Stam J, van Wijngaarden GK. Rhabdomyolysis and ­concomitant neurological lesions after intravenous heroin abuse. J Neurol Neurosurg Psychiatry. 1985;48:1057–9.

    Article  PubMed  Google Scholar 

  81. Roth D, Alarcon FJ, Fernandez JA, Preston RA, Bourgoignie JJ. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med. 1988;319:673–7.

    Article  PubMed  CAS  Google Scholar 

  82. Kendrick WC, Hull AR, Knochel JP. Rhabdomyolysis and shock after intravenous amphetamine administration. Ann Intern Med. 1977;86:381–7.

    Article  PubMed  CAS  Google Scholar 

  83. Cogen FC, Rigg G, Simmons JL, Domino EF. Phencyclidine-associated acute rhabdomyolysis. Ann Intern Med. 1978;88:210–2.

    Article  PubMed  CAS  Google Scholar 

  84. Macdonald JB, Jones HM, Cowan RA. Rhabdomyolysis and acute renal failure after theophylline overdose [letter]. Lancet. 1985;1:932–3.

    Article  PubMed  CAS  Google Scholar 

  85. Koppel C, Tenczer J, Ibe K. Poisoning with over-the-counter ­doxylamine preparations: an evaluation of 109 cases. Hum Toxicol. 1987;6:355–9.

    Article  PubMed  CAS  Google Scholar 

  86. Smals AG, Beex LV, Kloppenborg PW. Clofibrate-induced muscle damage with myoglobinuria and cardiomyopathy [letter]. N Engl J Med. 1977;296:942.

    PubMed  CAS  Google Scholar 

  87. Colombi A, Briner V, Truniger B. Rhabdomyolyse. Haufigkeit, Ursachen und Nachweis. Dtsch Med Wochenschr. 1985;110:1461–3.

    Article  PubMed  CAS  Google Scholar 

  88. Britt Jr CW, Light RR, Peters BH, Schochet Jr SS. Rhabdomyolysis during treatment with epsilon-aminocaproic acid. Arch Neurol. 1980;37:187–8.

    Article  PubMed  Google Scholar 

  89. Cho I, Bertorini JM, Hopkins L. Moxalactam myoclonus, seizures and encephalopathy. Drug Intell Clin Pharm. 1986;20:223–4.

    PubMed  CAS  Google Scholar 

  90. Schofield PM, Beath SV, Mant TG, Bhamra R. Recovery after severe oxprenolol overdose complicated by rhabdomyolysis. Hum Toxicol. 1985;4:57–60.

    Article  PubMed  CAS  Google Scholar 

  91. Koeffler HP, Haskell CM. Rhabdomyolysis as a complication of 5-azacytidine. Cancer Treat Rep. 1978;62:573–4.

    PubMed  CAS  Google Scholar 

  92. Toru M, Matsuda O, Makiguchi K, Sugano K. Neuroleptic ­malignant syndrome-like state following a withdrawal of antiparkinsonian drugs. J Nerv Ment Dis. 1981;169:324–7.

    Article  PubMed  CAS  Google Scholar 

  93. Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic ­treatment. Klin Wochenschr. 1983;61:303–5.

    Article  PubMed  CAS  Google Scholar 

  94. Barnes PC, Leonard JH. Hypokalaemic myopathy and myoglobinuria due to carbenoxolone sodium. Postgrad Med J. 1971;47:813–4.

    Article  PubMed  CAS  Google Scholar 

  95. Ownby CL, Odell GV. Pathogenesis of skeletal muscle necrosis induced by tarantula venom. Exp Mol Pathol. 1983;38:283–96.

    Article  PubMed  CAS  Google Scholar 

  96. Berlin R. Haff disease in Sweden. Acta Med Scand. 1948;129:560–72.

    Article  PubMed  CAS  Google Scholar 

  97. Rosner F. Biblical quail incident. JAMA. 1970;211:1544.

    Article  PubMed  CAS  Google Scholar 

  98. Demos MA, Gitin EL. Acute exertional rhabdomyolysis. Arch Intern Med. 1974;133:233–9.

    Article  PubMed  CAS  Google Scholar 

  99. Vertel RM, Knochel JP. Acute renal failure due to heat injury. An analysis of ten cases associated with a high incidence of ­myoglobinuria. Am J Med. 1967;43:435–51.

    Article  PubMed  CAS  Google Scholar 

  100. Os I, Lyngdal PT. General convulsions and rhabdomyolysis. Case reports. Acta Neurol Scand. 1989;79:246–8.

    Article  PubMed  CAS  Google Scholar 

  101. Singhal PC, Chugh KS, Gulati DR. Myoglobinuria and renal ­failure after status epilepticus. Neurology. 1978;28:200–1.

    Article  PubMed  CAS  Google Scholar 

  102. Chugh KS, Singhal PC, Khatri GK. Rhabdomyolysis and renal failure following status asthmaticus. Chest. 1978;73:879–80.

    Article  PubMed  CAS  Google Scholar 

  103. Langston JW, Ricci DR, Portlock C. Nonhypoxemic hazards of prolonged myoclonus. Neurology. 1977;27:542–5.

    Article  PubMed  CAS  Google Scholar 

  104. Jankovic J, Penn AS. Severe dystonia and myoglobinuria. Neurology. 1982;32:1195–7.

    Article  PubMed  CAS  Google Scholar 

  105. Coryell W, Norby LH, Cohen LH. Psychosis-induced rhabdomyolysis [letter]. Lancet. 1978;2:381–2.

    Article  PubMed  CAS  Google Scholar 

  106. Zelman S, Guillan R. Heat stroke in phenothiazine-treated patients: a report of three fatalities. Am J Psychiatry. 1970;126:1787–90.

    PubMed  CAS  Google Scholar 

  107. Schuman SH. Patterns of urban heat-wave deaths and implications for prevention: data from New York and St. Louis during July, 1966. Environ Res. 1972;5:59–75.

    Article  PubMed  CAS  Google Scholar 

  108. Helzlsouer KJ, Hayden FG, Rogol AD. Severe metabolic complications in a cross-country runner with sickle cell trait. JAMA. 1983;249:777–9.

    Article  PubMed  CAS  Google Scholar 

  109. Ron D, Taitelman U, Michaelson M, Bar Joseph G, Bursztein S, Better OS. Prevention of acute renal failure in traumatic rhabdomyolysis. Arch Intern Med. 1984;144:277–80.

    Article  PubMed  CAS  Google Scholar 

  110. Haimovici H. Metabolic complications of acute arterial occlusions. J Cardiovasc Surg (Torino). 1979;20:349–57.

    CAS  Google Scholar 

  111. Rosenthall L, Kloiber R, Gagnon R, Damtew B, Lough L. Frostbite with rhabdomyolysis and renal failure: radionuclide study. AJR Am J Roentgenol. 1981;137:387–90.

    Article  PubMed  CAS  Google Scholar 

  112. Yost JW, Holmes FF. Myoglobinuria following lightning stroke. JAMA. 1974;228:1147–8.

    Article  PubMed  CAS  Google Scholar 

  113. Dahlberg PJ, Howard RS. Rhabdomyolysis: an unusual postoperative complication. J Urol. 1982;127:520–1.

    PubMed  CAS  Google Scholar 

  114. Buckingham BA, Roe TF, Yoon JW. Rhabdomyolysis in diabetic ketoacidosis. Am J Dis Child. 1981;135:352–4.

    PubMed  CAS  Google Scholar 

  115. Singhal PC, Abramovici M, Venkatesan J. Rhabdomyolysis in the hyperosmolal state. Am J Med. 1990;88:9–12.

    Article  PubMed  CAS  Google Scholar 

  116. Halverson PB, Kozin F, Ryan LM, Sulaiman AR. Rhabdomyolysis and renal failure in hypothyroidism. Ann Intern Med. 1979;91:57–8.

    Article  PubMed  CAS  Google Scholar 

  117. Abe K, Mezaki T, Hirono N, Udaka F, Kameyama M. A case of anorexia nervosa with acute renal failure resulting from rhabdomyolysis. Acta Neurol Scand. 1990;81:82–3.

    Article  PubMed  CAS  Google Scholar 

  118. Bierbach H, Bohl J, Goldner HJ, Majdandzic J. Hypokalemic rhabdomyolysis associated with Bartter’s syndrome. Klin Wochenschr. 1983;61:183–6.

    Article  PubMed  CAS  Google Scholar 

  119. Campion DS, Arias JM, Carter NW. Rhabdomyolysis and ­myoglobinuria. Association with hypokalemia of renal tubular acidosis. JAMA. 1972;220:967–9.

    Article  PubMed  CAS  Google Scholar 

  120. Nadel SM, Jackson JW, Ploth DW. Hypokalemic rhabdomyolysis and acute renal failure. Occurrence following total parenteral nutrition. JAMA. 1979;241:2294–6.

    Article  PubMed  CAS  Google Scholar 

  121. Rumpf KW, Kaiser H, Schulze F, Koop H, Trapp VE. Myoglobinuria in malabsorption after small bowel resection. Myoglobinurie bei Malabsorption nach Dunndarm- resektion. Med Klin. 1981;76:563–4.

    PubMed  CAS  Google Scholar 

  122. Sidi Y, Gassner S, Sandbank U, Keren G, Pinkhas J. Water ­intoxication, hyperpyrexia and rhabdomyolysis in a patient with psychogenic polydipsia. N Y State J Med. 1984;84:462–4.

    PubMed  CAS  Google Scholar 

  123. Gamboa ET, Eastwood AB, Hays AP, Maxwell J, Penn AS. Isolation of influenza virus from muscle in myoglobinuric ­polymyositis. Neurology. 1979;29:1323–35.

    Article  PubMed  CAS  Google Scholar 

  124. Kagen LJ. Myoglobinemia and myoglobinuria in patients with myositis. Arthritis Rheum. 1971;14:457–64.

    Article  PubMed  CAS  Google Scholar 

  125. el Nahas AM, Farrington K, Quyyumi S, Moorhead JF, Sweny P. Rhabdomyolysis and systemic infection. Br Med J (Clin Res Ed). 1983;286:349–50.

    Article  Google Scholar 

  126. Berg P, Frenkel EP. Myoglobinuria after spontaneous and induced fever: report of a case. Ann Intern Med. 1958;48:380–9.

    Article  PubMed  CAS  Google Scholar 

  127. Rheingold OJ, Greenwald RA, Hayes PJ, Tedesco FJ. Myoglobinuria and renal failure associated with typhoid fever. JAMA. 1977;238:341.

    Article  PubMed  CAS  Google Scholar 

  128. Adamski GB, Garin EH, Ballinger WE, Shulman ST. Generalized nonsuppurative myositis with staphylococcal septicemia. J Pediatr. 1980;96:694–7.

    Article  PubMed  CAS  Google Scholar 

  129. Aouina H, Aïssa I, Baccar MA, Gharbi L, Azzabi S, Bouacha H. Acute rhabdomyolysis during pneumococcal pneumonia: two cases. Rev Pneumol Clin. 2007;63:105–8.

    Article  PubMed  CAS  Google Scholar 

  130. Blanco JR, Zabalza M, Salcedo J, San Román J. Rhabdomyolysis as a result of Streptococcus pneumoniae: report of a case and review. Clin Microbiol Infect. 2003;9:944–8.

    Article  PubMed  CAS  Google Scholar 

  131. Henrich WL, Prophet D, Knochel JP. Rhabdomyolysis associated with Escherichia coli septicemia. South Med J. 1980;73:936–7.

    Article  PubMed  CAS  Google Scholar 

  132. Hall SL, Wasserman M, Dall L, Schubert T. Acute renal failure secondary to myoglobinuria associated with Legionnaires’ disease. Chest. 1983;84:633–5.

    Article  PubMed  CAS  Google Scholar 

  133. Ho KJ, Scully KT. Acute rhabdomyolysis and renal failure in Weil’s disease. Ala J Med Sci. 1980;17:133–7.

    PubMed  CAS  Google Scholar 

  134. Falasca GF, Reginato AJ. The spectrum of myositis and rhabdomyolysis associated with bacterial infection. J Rheumatol. 1994;21:1932–7.

    PubMed  CAS  Google Scholar 

  135. Bachhuber R, Parker RA, Bennett WM. Acute renal failure in toxic shock syndrome owing to rhabdomyolysis. Ann Clin Lab Sci. 1983;13:25–6.

    PubMed  CAS  Google Scholar 

  136. Korman TM, Boers A, Gooding TM, Curtis N, Visvanathan K. Fatal case of toxic shock syndrome due to Group C streptococcus associated with superantigen exotoxin. J Clin Microbiol. 2004;42:2866–9.

    Article  PubMed  Google Scholar 

  137. Zamkoff K, Rosen N. Influenza and myoglobinuria in brothers. Neurology. 1979;29:340–5.

    Article  PubMed  CAS  Google Scholar 

  138. Kantor RJ, Norden CW, Wein TP. Infectious mononucleosis associated with rhabdomyolysis and renal failure. South Med J. 1978;71:346–8.

    Article  PubMed  CAS  Google Scholar 

  139. Dunett J. Acute renal failure and Coxsackie viral infection. Clin Nephrol. 1981;16:262–3.

    Google Scholar 

  140. Schlesinger JJ, Gandara D, Bensch KG. Myoglobinuria associated with herpes-group viral infections. Arch Intern Med. 1978;138:422–4.

    Article  PubMed  CAS  Google Scholar 

  141. Wright J, Couchonnal G, Hodges GR. Adenovirus type 21 infection. Occurrence with pneumonia, rhabdomyolysis, and myoglobinuria in an adult. JAMA. 1979;241:2420–1.

    Article  PubMed  CAS  Google Scholar 

  142. Jehn UW, Fink MK. Myositis, myoglobinemia, and myoglobinuria associated with enterovirus echo 9 infection. Arch Neurol. 1980;37:457–8.

    Article  PubMed  CAS  Google Scholar 

  143. Younger DS, Hays AP, Uncini A, Lange DJ, Lovelace RE, DiMauro S. Recurrent myoglobinuria and HIV seropositivity: incidental or pathogenic association? Muscle Nerve. 1989;12:842–3.

    Article  PubMed  CAS  Google Scholar 

  144. Bonnor R, Siddiqui M, Ahuja TS. Rhabdomyolysis associated with near-drowning. Am J Med Sci. 1999;318:201–2.

    Article  PubMed  CAS  Google Scholar 

  145. Agar JW. Rhabdomyolysis and acute renal failure after near-drowning in cold salt water. Med J Aust. 1994;161:686–7.

    PubMed  CAS  Google Scholar 

  146. Hue V, Martinot A, Fourier C, Cremer R, Leteurtre S, Leclerc F. [Acute rhabdomyolysis in the child]. Rhabdomyolyses aigues de l’enfant. Arch Pediatr. 1998;5:887–95.

    Article  PubMed  CAS  Google Scholar 

  147. Nakanishi K, Shimamoto S, Kishi M, Yoshioka T, Ishida T, Tomoda K, et al. CT, MR imaging and muscle biopsy in severe crush injury. Acta Radiol. 1997;38:903–6.

    PubMed  CAS  Google Scholar 

  148. Karajaia V, Mansour W, Kellum JA. Diuretics in acute kidney injury. Minerva Anestesiol. 2009;75:251–7.

    Google Scholar 

  149. Chaikin HL. Rhabdomyolysis secondary to drug overdose and prolonged coma. South Med J. 1980;73:990–4.

    Article  PubMed  CAS  Google Scholar 

  150. Visweswaran P, Guntupalli J. Rhabdomyolysis. Crit Care Clin. 1999;15:415–28.

    Article  PubMed  CAS  Google Scholar 

  151. Peltonen S, Ahlström A, Kylävainio V, Honkanen E, Pettilä V. The effect of combining intermittent hemodiafiltration with forced alkaline diuresis on plasma myoglobin in rhabdomyolysis. Acta Anaesthesiol Scand. 2007;51:553–8.

    Article  PubMed  CAS  Google Scholar 

  152. Prendergast BD, George CF. Drug-induced rhabdomyolysis–mechanisms and management. Postgrad Med J. 1993;69:333–6.

    Article  PubMed  CAS  Google Scholar 

  153. Better OS, Rubinstein I, Winaver J. Recent insights into the pathogenesis and early management of the crush syndrome. Semin Nephrol. 1992;12:217–22.

    PubMed  CAS  Google Scholar 

  154. Wagenmakers AJ, Coakley JH, Edwards RH. Metabolism of branched-chain amino acids and ammonia during exercise: clues from McArdle’s disease. Int J Sports Med. 1990;11 Suppl 2Suppl 2:S101–13.

    Article  PubMed  Google Scholar 

  155. Brumback RA, Feeback DL, Leech RW. Rhabdomyolysis in childhood. A primer on normal muscle function and selected metabolic myopathies characterized by disordered energy production. Pediatr Clin North Am. 1992;39:821–58.

    PubMed  CAS  Google Scholar 

  156. Wong PW, Dillard TA, Kroenke K. Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy. South Med J. 1998;91:202–5.

    Article  PubMed  CAS  Google Scholar 

  157. Meier C, Stey C, Brack T, Maggiorini M, Risti B, Krahenbuhl S. [Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity] Rhabdomyolyse bei mit Simvastatin und Ciclosporin behandelten Patienten: Rolle der Aktivitat des Cytochrom-P450-Enzymsystems der Leber. Schweiz Med Wochenschr. 1995;125:1342–6.

    PubMed  CAS  Google Scholar 

  158. Farmer JA, Gotto Jr AM. Antihyperlipidaemic agents. Drug interactions of clinical significance. Drug Saf. 1994;11:301–9.

    Article  PubMed  CAS  Google Scholar 

  159. Gilad R, Lampl Y. Rhabdomyolysis induced by simvastatin and ketoconazole treatment. Clin Neuropharmacol. 1999;22:295–7.

    PubMed  CAS  Google Scholar 

  160. Poels PJE, Gabreëls FJM. Rhabdomyolysis: a review of the literature. Clini Neurol Neurosurg. 1993;95:177.

    Google Scholar 

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Jadhav, D., Kaminski, H.J. (2014). Rhabdomyolysis and Myoglobinuria. In: Katirji, B., Kaminski, H., Ruff, R. (eds) Neuromuscular Disorders in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6567-6_78

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