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Approach to Small Fiber Neuropathy

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Neuromuscular Disorders in Clinical Practice

Abstract

Small fiber neuropathy (SFN) is due to damage of small-caliber somatic and/or autonomic nerve fibers. It often results in neuropathic pain which may dominate the clinical picture. This chapter discusses the small nerve fibers, thermosensory and nociceptive functions, and small fiber neuropathy. It also includes a brief discussion of testing of small and autonomic fiber functions, though more detailed descriptions are highlighted in Chaps. 10, 11, and 13. Neuropathic pain is discussed in Chap. 80.

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Authors and Affiliations

  1. Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, via Celoria, 11, Milan, 20133, Italy

    Giuseppe Lauria MD

  2. Department of Neurology, Spaarne Hospital, Hoofddorp, The Netherlands

    Ingemar S. J. Merkies MD, PhD

  3. Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands

    Ingemar S. J. Merkies MD, PhD & Catharina G. Faber MD, PhD

  4. Department of Neurology, Yale University School of Medicine, and Center for Neuroscience and Regeneration Research, Veterans Affairs Medical Center, West Haven, CT, USA

    Stephen G. Waxman MD, PhD

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  1. Giuseppe Lauria MD
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  2. Ingemar S. J. Merkies MD, PhD
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  3. Stephen G. Waxman MD, PhD
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  4. Catharina G. Faber MD, PhD
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Correspondence to Giuseppe Lauria MD .

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Editors and Affiliations

  1. School of Medicine Department of Neurology, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio, USA

    Bashar Katirji

  2. Department of Neurology, George Washington University, Washington, District of Columbia, USA

    Henry J. Kaminski

  3. University School of Medicine Department of Neurology, Louis Stokes Cleveland VA Medical Center Case Western Reserve, Cleveland, Ohio, USA

    Robert L. Ruff

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Lauria, G., Merkies, I.S.J., Waxman, S.G., Faber, C.G. (2014). Approach to Small Fiber Neuropathy. In: Katirji, B., Kaminski, H., Ruff, R. (eds) Neuromuscular Disorders in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6567-6_25

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