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Apoptosis-Inducing Factor 1, Mitochondrial

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Encyclopedia of Signaling Molecules

Abstract

Apoptosis-inducing factor (AIF); Programmed cell death protein 8 (PDCD8)

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References

  • Ardissone A, Piscosquito G, Legati A, Langella T, Lamantea E, Garavaglia B, et al. A slowly progressive mitochondrial encephalomyopathy widens the spectrum of AIFM1 disorders. Neurology. 2015;84:2193–5. doi:10.1212/WNL.0000000000001613.

    Article  PubMed  PubMed Central  Google Scholar 

  • Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010;29:1585–99. doi:10.1038/emboj.2010.43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cande C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, et al. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 2004;23:1514–21. doi:10.1038/sj.onc.1207279.

    Article  CAS  PubMed  Google Scholar 

  • Ferreira P, Villanueva R, Martínez-Júlvez M, Herguedas B, Marcuello C, Fernandez-Silva P, et al. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor. Biochemistry. 2014;53:4204–15. doi:10.1021/bi500343r.

    Article  CAS  PubMed  Google Scholar 

  • Ghezzi D, Sevrioukova I, Invernizzi F, Lamperti C, Mora M, D’Adamo P, et al. Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am J Hum Genet. 2010;86:639–49. doi:10.1016/j.ajhg.2010.03.002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, et al. Interaction between AIF and CHCHD4 regulates respiratory chain biogenesis. Mol Cell. 2015;58:1001–14. doi:10.1016/j.molcel.2015.04.020.

    Article  CAS  PubMed  Google Scholar 

  • Kettwig M, Schubach M, Zimmermann FA, Klinge L, Mayr JA, Biskup S, et al. From ventriculomegaly to severe muscular atrophy: expansion of the clinical spectrum related to mutations in AIFM1. Mitochondrion. 2015;21C:12–8. doi:10.1016/j.mito.2015.01.001.

    Article  Google Scholar 

  • Lui JC, Kong SK. Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis. FEBS Lett. 2007;581:109–17. doi:10.1016/j.febslet.2006.11.082.

    Article  CAS  PubMed  Google Scholar 

  • Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, et al. The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 2002;9:442–6. doi:10.1038/nsb793.

    Article  CAS  PubMed  Google Scholar 

  • Miramar MD, Costantini P, Ravagnan L, Saraiva LM, Haouzi D, Brothers G, et al. NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem. 2001;276:16391–8. doi:10.1074/jbc.M010498200.

    Article  CAS  PubMed  Google Scholar 

  • Modjtahedi N, Giordanetto F, Madeo F, Kroemer G. Apoptosis-inducing factor: vital and lethal. Trends Cell Biol. 2006;16:264–72. doi:10.1016/j.tcb.2006.03.008.

    Article  CAS  PubMed  Google Scholar 

  • Otera H, Ohsakaya S, Nagaura Z, Ishihara N, Mihara K. Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J. 2005;24:1375–86. doi:10.1038/sj.emboj.7600614.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rinaldi C, Grunseich C, Sevrioukova IF, Schindler A, Horkayne-Szakaly I, Lamperti C, et al. Cowchock syndrome is associated with a mutation in apoptosis-inducing factor. Am J Hum Genet. 2012;91:1095–102. doi:10.1016/j.ajhg.2012.10.008.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sevrioukova IF. Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal. 2011;14:2545–79. doi:10.1089/ars.2010.3445.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shelar SB, Kaminska KK, Reddy SA, Kumar D, Tan CT, Yu VC, et al. Thioredoxin-dependent regulation of AIF-mediated DNA damage. Free Radic Biol Med. 2015;87:FRBMD1500111. doi:10.1016/j.freeradbiomed.2015.06.029.

    Article  Google Scholar 

  • Sorrentino L, Calogero AM, Pandini V, Vanoni MA, Sevrioukova IF, Aliverti A. Key role of the adenylate moiety and integrity of the adenylate-binding site for the NAD(+)/H binding to mitochondrial apoptosis-inducing factor. Biochemistry. 2015;54:6996–7009. doi:10.1021/acs.biochem.5b00898.

    Article  CAS  PubMed  Google Scholar 

  • Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441–6. doi:10.1038/17135.

    Article  CAS  PubMed  Google Scholar 

  • Villanueva R, Ferreira P, Marcuello C, Usón A, Miramar MD, Peleato ML, et al. Key residues regulating the reductase activity of the human mitochondrial apoptosis inducing factor. Biochemistry. 2015;54:5175–84. doi:10.1021/acs.biochem.5b00696.

    Article  CAS  PubMed  Google Scholar 

  • Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, et al. DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol. 2002;9:680–4. doi:10.1038/nsb836.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank Luis Martinez Lostao (University of Zaragoza) for helping us with the graphical illustration in Figure 1.

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Correspondence to Patricia Ferreira .

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Ferreira, P., Villanueva, R., Martínez-Júlvez, M., Medina, M. (2016). Apoptosis-Inducing Factor 1, Mitochondrial. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101522-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101522-1

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