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Congenital Toxoplasmosis

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Atlas of Genetic Diagnosis and Counseling
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Abstract

Acute infection in a pregnant woman with a parasite, Toxoplasma gondii, can have serious consequences on the fetus, ranging from fetal loss to severe neurologic or ocular lesions. In other cases, infected newborns are asymptomatic at birth but are at risk for developing retinal diseases during childhood or adolescence on Toxoplasma reactivation (Wallon et al. 2004). In the United States, the incidence of congenital toxoplasmosis is estimated to be 1 in 1,000 to 1 in 10,000 births, and approximately 400–4,000 cases of congenital toxoplasmosis occur each year.

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References

  • Alford, C. A., Jr., Stagno, S., & Reynolds, D. W. (1974). Congenital toxoplasmosis: Clinical, laboratory, and therapeutic considerations with special reference to subclinical disease. Bulletin of the New York Academy of Medicine, 50, 160–181.

    PubMed  PubMed Central  Google Scholar 

  • Antsaklis, A., Daskalakis, G., Papantoniou, N., et al. (2002). Prenatal diagnosis of congenital toxoplasmosis. Prenatal Diagnosis, 22, 1107–1111.

    Article  PubMed  Google Scholar 

  • Beasley, D. M., & Egerman, R. S. (1998). Toxoplasmosis. Seminars in Perinatology, 22, 332–338.

    Article  Google Scholar 

  • Black, M. W., & Boothroyd, J. C. (2000). Lytic cycle of Toxoplasma gondii. Microbiology and Molecular Biology Reviews, 64, 607–623.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bollani, L., Strocchio, L., & Stronati, M. (2013). Congenital toxoplasmosis. Early Human Development, 89(Supplement 4), S70–S71.

    Article  Google Scholar 

  • Daffos, F., Forestier, F., Capella-Pavlovsky, M., et al. (1988). Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. The New England Journal of Medicine, 318, 271–275.

    Article  CAS  PubMed  Google Scholar 

  • Foulon, W., Pinon, J.-M., Stray-Pedersen, B., et al. (1999a). Prenatal diagnosis of congenital toxoplasmosis: A multicenter evaluation of different diagnostic parameter. American Journal of Obstetrics and Gynecology, 181, 843–847.

    Article  CAS  PubMed  Google Scholar 

  • Foulon, W., Villena, I., Stray-Pedersen, B., et al. (1999b). Treatment of toxoplasmosis during pregnancy: A multicenter study of impact on fetal transmission and children’s sequelae at age 1 year. American Journal of Obstetrics and Gynecology, 190, 410–415.

    Article  Google Scholar 

  • Fricker-Hidalgo, H., Pelloux, H., Muet, F., et al. (1997). Prenatal diagnosis of congenital toxoplasmosis: Comparative value of fetal blood and amniotic fluid using serological techniques and cultures. Prenatal Diagnosis, 17, 831–835.

    Article  CAS  PubMed  Google Scholar 

  • Guerina, N. G., Hsu, H.-W., Meissner, H. C., et al. (1994). Neonatal serologic screening and early treatment for congenital Toxoplasma gondii infection. The New England Regional Toxoplasma Working Group. The New England Journal of Medicine, 330, 1858–1863.

    Article  CAS  PubMed  Google Scholar 

  • Hall, S. M. (1992). Congenital toxoplasmosis. British Medical Journal, 305, 291–297.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hezard, N., Marx-Chemla, C., Foudrinier, F., et al. (1997). Prenatal diagnosis of congenital toxoplasmosis in 261 pregnancies. Prenatal Diagnosis, 17, 1047–1054.

    Article  CAS  PubMed  Google Scholar 

  • Hohlfeld, P., Daffos, F., Thulliez, P., et al. (1989). Fetal toxoplasmosis: Outcome of pregnancy and infant follow-up after in utero treatment. Journal of Pediatrics, 115, 765–769.

    Article  CAS  PubMed  Google Scholar 

  • Hohlfeld, P., Dafos, F., Costa, J. M., et al. (1994). Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid. The New England Journal of Medicine, 331, 695–699.

    Article  CAS  PubMed  Google Scholar 

  • Holec-Gasior, L. (2013). Toxoplasma gondii recombinant antigens as tools for serodiagnosis of human toxoplasmosis: Current status of studies. Clinical and Vaccine Immunology, 20, 1343–1351.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hovakimyan, A., & Cunningham, E. T., Jr. (2002). Ocular toxoplasmosis. Ophthalmology Clinics of North America, 15, 327–332.

    Article  PubMed  Google Scholar 

  • Jones, J., Lopez, A., & Wilson, M. (2003). Congenital toxoplasmosis. American Family Physician, 67, 2131–2138.

    PubMed  Google Scholar 

  • Kaye, A. (2011). Toxoplasmosis: diagnosis, treatment, and prevention in congenitally exposed infants. Journal of Pediatric Health Care, 25, 355–364.

    Article  PubMed  Google Scholar 

  • Lynfield, R., & Eaton, R. B. (1995). Teratogen update: Congenital toxoplasmosis. Teratology, 52, 176–180.

    Article  CAS  PubMed  Google Scholar 

  • Maenz, M., Schlüter, D., Liesenfeld, O., et al. (2014). Ocular toxoplasmosis past, present and new aspects of an old disease. Progress in Retinal and Eye Research, 39, 77–106.

    Article  CAS  PubMed  Google Scholar 

  • Melamed, J., Eckert, G., Spadoni, V. S., et al. (2010). Ocular manifestations of congenital toxoplasmosis. Eye, 24, 528–534.

    Article  CAS  PubMed  Google Scholar 

  • Metz, M. B. (2001). Eye manifestations of intrauterine infections. Ophthalmology Clinics of North America, 14, 521–531.

    Article  Google Scholar 

  • Naessens, A., Jenum, P. A., Pollak, A., et al. (1999). Diagnosis of congenital toxoplasmosis in the neonatal period: A multicenter evaluation. Journal of Pediatrics, 135, 714–719.

    Article  CAS  PubMed  Google Scholar 

  • Patel, D. V., Holfels, E. M., Vogel, N. P., et al. (1996). Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis. Radiology, 199, 433–440.

    Article  CAS  PubMed  Google Scholar 

  • Robert-Gangneux, F. (2014). It is not only the cat that did it: How to prevent and treat congenital toxoplasmosis. Journal of Infection, 68, S125–S133.

    Article  PubMed  Google Scholar 

  • Robert-Gangneux, F., Dupretz, P., Yvenou, C., et al. (2010). Clinical relevance of placenta examination for the diagnosis of congenital toxoplasmosis. The Pediatric Infectious Disease Journal, 29, 33–38.

    Article  PubMed  Google Scholar 

  • Roizen, N., Swisher, C. N., Stein, M. A., et al. (1995). Neurologic and developmental outcome in treated congenital toxoplasmosis. Pediatrics, 95, 11–20.

    CAS  PubMed  Google Scholar 

  • Wallon, M., Kodjikian, L., Binquet, C., et al. (2004). Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics, 113, 1567–1572.

    Article  PubMed  Google Scholar 

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Correspondence to Harold Chen .

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Chen, H. (2016). Congenital Toxoplasmosis. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6430-3_56-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6430-3_56-2

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  • Online ISBN: 978-1-4614-6430-3

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