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McCune-Albright Syndrome

Atlas of Genetic Diagnosis and Counseling

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Abstract

McCune in 1936 described a 9-year-old female with precocious puberty, hyperpigmentation of the skin, and hyperthyroidism (McCune and Bruch 1936). In 1937, Albright published a case series of five females with bone disease, areas of hyperpigmentation, and precocious puberty (Albright et al. 1937). McCune-Albright syndrome (MAS) consists of polyostotic fibrous dysplasia, precocious puberty, café au lait spots, and other endocrinopathies secondary to hyperactivity of various endocrine glands. It is a rare disease with an estimated prevalence between 1/100,000 and 1/1,000,000.

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Authors and Affiliations

  1. Shriners Hospitals for Children, 71130, Shreveport, LA, USA

    Harold Chen

  2. Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA

    Harold Chen

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  1. Harold Chen
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Correspondence to Harold Chen .

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Chen, H. (2015). McCune-Albright Syndrome. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6430-3_152-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6430-3_152-2

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6430-3

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Chapter history

  1. Latest

    McCune-Albright Syndrome
    Published:
    25 June 2016

    DOI: https://doi.org/10.1007/978-1-4614-6430-3_152-3

  2. Original

    McCune-Albright Syndrome
    Published:
    09 December 2015

    DOI: https://doi.org/10.1007/978-1-4614-6430-3_152-2

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