Skip to main content

Registration of Brain Tumor Images Using Hyper-Elastic Regularization

  • Conference paper
  • First Online:
Computational Biomechanics for Medicine

Abstract

In this paper, we present a method to estimate a deformation field between two instances of a brain volume having tumor. The novelties include the assessment of the disease progress by observing the healthy tissue deformation and usage of the Neo-Hookean strain energy density model as a regularizer in deformable registration framework. Implementations on synthetic and patient data provide promising results, which might have relevant use in clinical problems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    http://www.fil.ion.ucl.ac.uk/spm/

References

  1. Bower, A.F.: Applied Mechanics of Solids. Taylor and Francis Group, LLC (2010)

    Google Scholar 

  2. Clatz, O., Sermesant, M., Bondiau, P.Y., Delingette, H., Warfield, S., Malandain, G., Ayache. N.: Realistic simulation of the 3d growth of brain tumors in mr images coupling diffusion with biomechanical deformation. IEEE Trans. Med. Imag. 24(10), 1334–1346 (2005)

    Google Scholar 

  3. Davatzikos, C.: Spatial transformation and registration of brain images using elastically deformable models. Comput. Vis. Image Understand. 66(2), 207–222 (1997)

    Article  Google Scholar 

  4. Demir, A., Unal, G., Karaman, K.: Anatomical landmark based registration of contrast enhanced t1-weighted mr images. In: Proceedings of the 4th International Conference on Biomedical Image Registration, pp. 91–103. Springer, Berlin, Heidelberg, WBIR’10 (2010)

    Google Scholar 

  5. Hamamci, A., Kucuk, N., Karaman, K., Engin, K., Unal, G.: Tumor-cut: Segmentation of brain tumors on contrast enhanced mr images for radiosurgery applications. IEEE Trans. Med. Imag. 31(3), 790–804 (2012)

    Article  Google Scholar 

  6. Hogea, C., Biros, G., Abraham, F., Davatzikos, C.: A robust framework for soft tissue simulations with application to modeling brain tumor mass effect in 3D MR images. Phys. Med. Biol. 52(23), 6893 (2007)

    Article  Google Scholar 

  7. Joldes, G.R., Wittek, A., Miller, K.: Suite of finite element algorithms for accurate computation of soft tissue deformation for surgical simulation. Med. Image Anal. 13(6), 912–919 (2009)

    Article  Google Scholar 

  8. Konukoglu, E., Clatz, O., Bondiau, P.Y., Delingette, H., Ayache, N.: Extrapolating glioma invasion margin in brain magnetic resonance images: suggesting new irradiation margins. Med. Image Anal. 14(2), 111–125 (2010)

    Article  Google Scholar 

  9. Miller, K., Chinzei, K.: Mechanical properties of brain tissue in tension. J. Biomech. 35(4), 483–490 (2002)

    Article  Google Scholar 

  10. Mohamed, A., Davatzikos, C.: Finite element modeling of brain tumor mass-effect from 3D medical images. In: Proceedings of the 8th International Conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I, pp. 400–408. Springer, Berlin, Heidelberg, MICCAI’05 (2005)

    Google Scholar 

  11. Niethammer, M., Hart, G., Pace, D., Aylward, S.: Geometric metamorphosis. In: MICCAI (2011)

    Google Scholar 

  12. Pedregal, P.: Variational Methods in Nonlinear Elasticity. Society for Industrial and Applied Mathematics, Philadelphia, PA, USA (2000)

    Book  MATH  Google Scholar 

  13. Periaswamy, S., Farid, H.: Elastic registration with partial data. In: Proceedings of Workshop on Biomedical Image Registration WBIR03, pp. 102–111 (2003)

    Google Scholar 

  14. Prastawa, M., Bullitt, E., Gerig, G.: Simulation of brain tumors in MR images for evaluation of segmentation efficacy. Med. Image Anal. 13(2), 297–311 (2009)

    Article  Google Scholar 

  15. Reuter, M., Rosas, H.D., Fischl, B.: Highly accurate inverse consistent registration: a robust approach. NeuroImage 53(4), 1181–1196 (2010)

    Article  Google Scholar 

  16. Wittek, A., Miller, K., Kikinis, R., Warfield, S.K.: Patient-specific model of brain deformation: Application to medical image registration. J. Biomech. 40(4), 919–929 (2007)

    Article  Google Scholar 

  17. Wittek, A., Hawkins, T., Miller, K.: On the unimportance of constitutive models in computing brain deformation for image-guided surgery. Biomech. Model. Mechanobiology 8, 77–84 (2009)

    Article  Google Scholar 

  18. Yanovsky, I., Le Guyader, C., Leow, A., Toga, A.W., Thompson, P.M., Vese, L.: Unbiased volumetric registration via nonlinear elastic regularization. In: Pennec, X. (ed.) 2nd MICCAI Workshop on Mathematical Foundations of Computational Anatomy, New York, États-Unis (2008)

    Google Scholar 

Download references

Acknowledgments

This work was partially supported by TUBA-GEBIP (Turkish Academy of Sciences) and EU FP7 Grant No: PIRG03-GA-2008-231052.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gozde Unal .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this paper

Cite this paper

Hamamci, A., Unal, G. (2013). Registration of Brain Tumor Images Using Hyper-Elastic Regularization. In: Wittek, A., Miller, K., Nielsen, P. (eds) Computational Biomechanics for Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6351-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6351-1_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6350-4

  • Online ISBN: 978-1-4614-6351-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics