Skip to main content

Tools and Techniques for Gastrointestinal Hemostasis

  • Chapter
  • First Online:
Principles of Flexible Endoscopy for Surgeons

Abstract

Acute gastrointestinal (GI) bleeding can be amongst the most challenging GI conditions for care givers and is optimally managed in a multidisciplinary fashion. Team members can be highly variable and may include an emergency room physician, interventional radiologist or vascular surgeon, gastroenterologist, intensivist, and surgeon or surgical endoscopist. It is vital to have clear, concise, and current communication among team members to optimize outcome for the patient. Each member has a critical role from initiating resuscitation promptly in the emergency room, to endoscopic diagnostic and therapeutic management, to endovascular or interventional radiologic strategies if endoscopic therapies fail, and finally to post-procedure support and monitoring of the patient. This chapter provides an in-depth look at the tools used to gain endoscopic hemostasis in the GI tract. Basic elements of the proper evaluation and preparation of a patient for endoscopic therapy of GI bleeding are also covered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lau JY, Leung WK, Wu JC, et al. Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med. 2007;356(16):1631–40.

    Article  PubMed  CAS  Google Scholar 

  2. Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316–21.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  3. Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000;356(9238):1318–21.

    Article  PubMed  CAS  Google Scholar 

  4. Foster DN, Miloszewski KJ, Losowsky MS. Stigmata of recent haemorrhage in diagnosis and prognosis of upper gastrointestinal bleeding. Br Med J. 1978;1(6121):1173–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. Cappell MS, Friedel D. Initial management of acute upper gastrointestinal bleeding: from initial evaluation up to gastrointestinal endoscopy. Med Clin North Am. 2008;92(3):491–509. xi.

    Article  PubMed  Google Scholar 

  6. Coffin B, Pocard M, Panis Y, et al. Erythromycin improves the quality of EGD in patients with acute upper GI bleeding: a randomized controlled study. Gastrointest Endosc. 2002;56(2):174–9.

    Article  PubMed  Google Scholar 

  7. Barkun AN, Bardou M, Kuipers EJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101–13.

    Article  PubMed  Google Scholar 

  8. Kubba AK, Palmer KR. Role of endoscopic injection therapy in the treatment of bleeding peptic ulcer. Br J Surg. 1996;83(4):461–8.

    Article  PubMed  CAS  Google Scholar 

  9. Calvet X, Vergara M, Brullet E, Gisbert JP, Campo R. Addition of a second endoscopic treatment following epinephrine injection improves outcome in high-risk bleeding ulcers. Gastroenterology. 2004;126(2):441–50.

    Article  PubMed  Google Scholar 

  10. Brullet E, Calvet X, Campo R, Rue M, Catot L, Donoso L. Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer. Gastrointest Endosc. 1996;43(2 Pt 1):111–6.

    Article  PubMed  CAS  Google Scholar 

  11. Schmitz RJ, Sharma P, Badr AS, Qamar MT, Weston AP. Incidence and management of esophageal stricture formation, ulcer bleeding, perforation, and massive hematoma formation from sclerotherapy versus band ligation. Am J Gastroenterol. 2001;96(2):437–41.

    Article  PubMed  CAS  Google Scholar 

  12. Dorta G, Michetti P, Burckhardt P, Gillet M. Acute ischemia followed by hemorrhagic gastric necrosis after injection sclerotherapy for ulcer. Endoscopy. 1996;28(6):532.

    Article  PubMed  CAS  Google Scholar 

  13. Scharnke W, Hust MH, Braun B, Schumm W. Complete gastric wall necrosis after endoscopic sclerotherapy for a gastric ulcer with visible arterial stump. Dtsch Med Wochenschr. 1997;122(19):606–9.

    Article  PubMed  CAS  Google Scholar 

  14. Kitano S, Hashizume M, Yamaga H, et al. Human thrombin plus 5 per cent ethanolamine oleate injected to sclerose oesophageal varices: a prospective randomized trial. Br J Surg. 1989;76(7):715–8.

    Article  PubMed  CAS  Google Scholar 

  15. Spotnitz WD, Prabhu R. Fibrin sealant tissue adhesive—review and update. J Long Term Eff Med Implants. 2005;15(3):245–70.

    Article  PubMed  Google Scholar 

  16. Rutgeerts P, Rauws E, Wara P, et al. Randomised trial of single and repeated fibrin glue compared with injection of polidocanol in treatment of bleeding peptic ulcer. Lancet. 1997;350(9079):692–6.

    Article  PubMed  CAS  Google Scholar 

  17. Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology. 1992;16(6):1343–9.

    Article  PubMed  CAS  Google Scholar 

  18. Cheng LF, Wang ZQ, Li CZ, et al. Treatment of gastric varices by endoscopic sclerotherapy using butyl cyanoacrylate: 10 years’ experience of 635 cases. Chin Med J (Engl). 2007;120(23):2081–5.

    Google Scholar 

  19. Lee KJ, Kim JH, Hahm KB, Cho SW, Park YS. Randomized trial of N-butyl-2-cyanoacrylate compared with injection of hypertonic saline-epinephrine in the endoscopic treatment of bleeding peptic ulcers. Endoscopy. 2000;32(7):505–11.

    Article  PubMed  CAS  Google Scholar 

  20. Jensen DM, Machicado GA. Hemoclipping of chronic canine ulcers: a randomized, prospective study of initial deployment success, clip retention rates, and ulcer healing. Gastrointest Endosc. 2009;70(5):969–75.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Cho I, Gaslightwala I, Jensen DM, Cohen J. Endoclip therapy in the gastrointestinal tract: bleeding lesions and beyond UpToDate [online]. 2009. http://www.utdol.com/patients/content/topic.do. Accessed 27 May 2012.

  22. Lin HJ, Hsieh YH, Tseng GY, Perng CL, Chang FY, Lee SD. A prospective, randomized trial of endoscopic hemoclip versus heater probe thermocoagulation for peptic ulcer bleeding. Am J Gastroenterol. 2002;97(9):2250–4.

    Article  PubMed  Google Scholar 

  23. Chung IK, Ham JS, Kim HS, Park SH, Lee MH, Kim SJ. Comparison of the hemostatic efficacy of the endoscopic hemoclip method with hypertonic saline-epinephrine injection and a combination of the two for the management of bleeding peptic ulcers. Gastrointest Endosc. 1999;49(1):13–8.

    Article  PubMed  CAS  Google Scholar 

  24. Vergara M, Calvet X, Gisbert JP. Epinephrine injection versus epinephrine injection and a second endoscopic method in high risk bleeding ulcers. Cochrane Database Syst Rev (Online). 2007(2):CD005584.

    Google Scholar 

  25. Cipolletta L, Bianco MA, Marmo R, et al. Endoclips versus heater probe in preventing early recurrent bleeding from peptic ulcer: a prospective and randomized trial. Gastrointest Endosc. 2001;53(2): 147–51.

    Article  PubMed  CAS  Google Scholar 

  26. Shin EJ, Ko CW, Magno P, et al. Comparative study of endoscopic clips: duration of attachment at the site of clip application. Gastrointest Endosc. 2007;66(4):757–61.

    Article  PubMed  Google Scholar 

  27. Gill KR, Pooley RA, Wallace MB. Magnetic resonance imaging compatibility of endoclips. Gastrointest Endosc. 2009;70(3):532–6.

    Article  PubMed  Google Scholar 

  28. Eriksson LG, Sundbom M, Gustavsson S, Nyman R. Endoscopic marking with a metallic clip facilitates transcatheter arterial embolization in upper peptic ulcer bleeding. J Vasc Interv Radiol. 2006;17(6):959–64.

    Article  PubMed  Google Scholar 

  29. Lo GH, Lai KH, Cheng JS, Huang RL, Wang SJ, Chiang HT. Prevalence of paraesophageal varices and gastric varices in patients achieving variceal obliteration by banding ligation and by injection sclerotherapy. Gastrointest Endosc. 1999;49(4 Pt 1):428–36.

    Article  PubMed  CAS  Google Scholar 

  30. Merkel C, Zoli M, Siringo S, et al. Prognostic indicators of risk for first variceal bleeding in cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic Club (NIEC) index. Am J Gastroenterol. 2000;95(10):2915–20.

    Article  PubMed  CAS  Google Scholar 

  31. Baron TH, Wong Kee Song LM. Endoscopic variceal band ligation. Am J Gastroenterol. 2009;104(5):1083–5.

    Article  PubMed  Google Scholar 

  32. Liu J, Petersen BT, Tierney WM, et al. Endoscopic banding devices. Gastrointest Endosc. 2008;68(2):217–21.

    Article  PubMed  Google Scholar 

  33. Sarin SK, Lamba GS, Kumar M, Misra A, Murthy NS. Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med. 1999;340(13):988–93.

    Article  PubMed  CAS  Google Scholar 

  34. Masci E, Stigliano R, Mariani A, et al. Prospective multicenter randomized trial comparing banding ligation with sclerotherapy of esophageal varices. Hepatogastroenterology. 1999;46(27):1769–73.

    PubMed  CAS  Google Scholar 

  35. Bernard B, Grange JD, Khac EN, Amiot X, Opolon P, Poynard T. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology. 1999;29(6):1655–61.

    Article  PubMed  CAS  Google Scholar 

  36. Paspatis GA, Charoniti I, Papanikolaoi N, et al. A prospective randomized comparison of 10-Fr versus 7-Fr bipolar electrocoagulation catheter in combination with adrenaline injection n the endoscopic treatment of bleeding peptic ulcers. Am J Gastroenterol. 2003;98(10):2192–7.

    Article  PubMed  Google Scholar 

  37. Kovacs TO, Jensen DM. Endoscopic treatment of ulcer bleeding. Curr Treat Options Gastroenterol. 2007;10(2):143–8.

    Article  PubMed  Google Scholar 

  38. Lecleire S, Ben-Soussan E, Antonietti M, et al. Bleeding gastric vascular ectasia treated by argon plasma coagulation: a comparison between patients with and without cirrhosis. Gastrointest Endosc. 2008;67(2):219–25.

    Article  PubMed  Google Scholar 

  39. Olmos JA, Marcolongo M, Pogorelsky V, Herrera L, Tobal F, Davolos JR. Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. Dis Colon Rectum. 2006;49(10):1507–16.

    Article  PubMed  Google Scholar 

  40. Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343(5):310–6.

    Article  PubMed  CAS  Google Scholar 

  41. Jensen DM. Management of severe ulcer rebleeding. N Engl J Med. 1999;340(10):799–801.

    Article  PubMed  CAS  Google Scholar 

  42. Mellinger JD, MacFadyen BV, Kozarek RA, Soper ND, Birkett DH, Swanstrom LL. Initial experience with a novel endoscopic device allowing intragastric manipulation and plication. Surg Endosc. 2007;21(6):1002–5.

    Article  PubMed  Google Scholar 

  43. Heylen AM, Jacobs A, Lybeer M, Prosst RL. The OTSC(R)-clip in revisional endoscopy against weight gain after bariatric gastric bypass surgery. Obes Surg. 2011;21(10):1629–33.

    Article  PubMed  Google Scholar 

  44. Kouklakis G, Zezos P, Liratzopoulos N, et al. Endoscopic treatment of a gastrocutaneous fistula using the over-the-scope-clip system: a case report. Diagn Ther Endosc. 2011;2011:384143.

    PubMed  PubMed Central  Google Scholar 

  45. Pohl J, Borgulya M, Lorenz D, Ell C. Endoscopic closure of postoperative esophageal leaks with a novel over-the-scope clip system. Endoscopy. 2010;42(9):757–9.

    Article  PubMed  CAS  Google Scholar 

  46. Prosst RL, Herold A, Joos AK, et al. The ‘Anal Fistula Claw’: the OTSC-clip for anal fistula closure. Colorectal Dis. 2011;14(9):1112–7.

    Google Scholar 

  47. Jirapinyo P, Watson RR, Thompson CC. Use of a novel endoscopic suturing device to treat recalcitrant marginal ulceration (with video). Gastrointest Endosc. 2012;76:435–9.

    Article  PubMed  Google Scholar 

  48. Kantsevoy SV, Thuluvath PJ. Successful closure of a chronic refractory gastrocutaneous fistula with a new endoscopic suturing device (with video). Gastrointest Endosc. 2012;75(3):688–90.

    Article  PubMed  Google Scholar 

  49. von Renteln D, Schmidt A, Riecken B, Caca K. Gastric full-thickness suturing during EMR and for treatment of gastric-wall defects (with video). Gastrointest Endosc. 2008;67(4):738–44.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John D. Mellinger M.D., F.A.C.S. .

Editor information

Editors and Affiliations

Electronic supplementary material

Below is the link to the electronic supplementary material.

Active arterial bleeding from a polypectomy site (Video courtesy of Aman Ali, MD) (AVI 44949 kb)

Same site as depicted in video one after control with an endoscopically placed clip (Video courtesy of Aman Ali, MD) (AVI 23094 kb)

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ahad, S., Mellinger, J.D. (2013). Tools and Techniques for Gastrointestinal Hemostasis. In: Marks, J., Dunkin, B. (eds) Principles of Flexible Endoscopy for Surgeons. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6330-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6330-6_8

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6329-0

  • Online ISBN: 978-1-4614-6330-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics