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Human T Follicular Helper Cells: Development and Subsets

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Crossroads Between Innate and Adaptive Immunity IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 785))

Abstract

Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4+ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.

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Acknowledgments

We thank former and current members of the Institute for their contributions to our progresses. These studies have been supported by the NIH (P01 CA084514, U19 AI057234, U19 AI082715, and U19 AI089987), the Baylor Health Care System; the Baylor Health Care System Foundation.

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Authors and Affiliations

  1. Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX, 75204, USA

    Nathalie Schmitt Ph.D. & Hideki Ueno M.D., Ph.D.

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  1. Nathalie Schmitt Ph.D.
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  2. Hideki Ueno M.D., Ph.D.
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Correspondence to Hideki Ueno M.D., Ph.D. .

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Editors and Affiliations

  1. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  2. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

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Schmitt, N., Ueno, H. (2013). Human T Follicular Helper Cells: Development and Subsets. In: Katsikis, P., Schoenberger, S., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity IV. Advances in Experimental Medicine and Biology, vol 785. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6217-0_10

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