Cronkhite–Canada Syndrome: Dermatological Features

Abstract

Clinical signs and features include:

Dermatological triad:

1. Hyperpigmentation: macules and papules (lentigo-like), light to dark brown, a few mm to 10 cm in diameter, diffusely located but most commonly on the hands, feet, face, lips, buccal mucosa

2. Nail changes: dystrophy, onycholysis, unique inverted triangle of inverted normal nail bordered by dystrophic nail.

3. Alopecia: rapidly progressive, patchy but leading to complete hair loss: also facial, axillary, extremity, and pubic hair loss.

Median age diagnosis, 59 years old.

Males > females

Since 1955, there have been 400 cases, 75 % in Japan, 15 % develop malignancy most commonly of the sigmoid colon and rectum.