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Host–Pathogen Specificity in Tuberculosis

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The New Paradigm of Immunity to Tuberculosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 783))

Abstract

The host response to mycobacterial infection including tuberculosis depends on genetically controlled host and bacterial factors and their interaction. A largely unknown aspect of this interaction is whether disease results from an additive and independent effect of host and pathogen or from specific host–pathogen combinations. The preferential association of specific mycobacterial strains with specific ethnic groups provided tentative evidence in favor of host–pathogen specificity in tuberculosis and is consistent with the hypothesis of host–mycobacterial co-adaptation. Substantial evidence for specificity has now been provided by animal models and human case–control association studies. These studies indicate that differences in the host response to infection are at least in part due to specific combinations of host genetic factors and genetic and phenotypic characteristics of the infecting mycobacterial strain.

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Authors and Affiliations

  1. McGill University Health Centre McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, 1650 Cedar Avenue, Room L11.521, Montreal, H3G 1A4, QC, Canada

    Erwin Schurr

  2. McGill University Health Centre McGill Centre for the Study of Host Resistance, Departments of Medicine and Human Genetics, 1650 Cedar Avenue, Room L11.520, Montreal, H3G 1A4, QC, Canada

    Tania Di Pietrantonio

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  1. Tania Di Pietrantonio
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  2. Erwin Schurr
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Correspondence to Erwin Schurr .

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Editors and Affiliations

  1. McGill University, Montreal, H2X 2P2, Québec, Canada

    Maziar Divangahi

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Di Pietrantonio, T., Schurr, E. (2013). Host–Pathogen Specificity in Tuberculosis. In: Divangahi, M. (eds) The New Paradigm of Immunity to Tuberculosis. Advances in Experimental Medicine and Biology, vol 783. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6111-1_2

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