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Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers

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Molecular Pathology of Neoplastic Gastrointestinal Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 7))

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Abstract

Clinical applications of genomic medicine and molecular diagnostics based on testing of tumor tissues are becoming a reality in clinical practice, with significant impact on personalized therapies for cancer patients. Advances in targeted therapies for cancers of the gastrointestinal tract have recently emerged and are rapidly moving targets. In this chapter, we review the targeted therapies that are currently standard of practice in colorectal and gastric cancers, requiring specific molecular testing for selection of candidate patients for therapy.

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Authors and Affiliations

  1. Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, R35, Cleveland, OH, 44195, USA

    Davendra Sohal M.D., M.P.H.

  2. Department of Pathology & Cell Biology, Columbia University, 630 W 168th Street, VC-14 RM 212, New York, NY, 10032, USA

    Antonia R. Sepulveda M.D., Ph.D.

  3. Department of Medicine, Hematology-Oncology, University of Pittsburgh School of Medicine, UPMC Cancer Pavilion, 5150 Centre Avenue, Fifth Floor, Pittsburgh, PA, 15232, USA

    Weijing Sun M.D.

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  1. Davendra Sohal M.D., M.P.H.
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  2. Antonia R. Sepulveda M.D., Ph.D.
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Correspondence to Weijing Sun M.D. .

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Editors and Affiliations

  1. Department of Pathology & Cell Biology, Columbia University, New York, 10032, New York, USA

    Antonia R. Sepulveda

  2. Division of Gastroenterology, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA

    John P. Lynch

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Sohal, D., Sepulveda, A.R., Sun, W. (2013). Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers. In: Sepulveda, A., Lynch, J. (eds) Molecular Pathology of Neoplastic Gastrointestinal Diseases. Molecular Pathology Library, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6015-2_2

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