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Hypoxia and Regulation of Cancer Cell Stemness

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Tumor Microenvironment and Cellular Stress

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 772))

Abstract

Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell “stemness.” Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant effect on the evolution of different clonal populations. Hypoxia is a common feature of tumor microenvironments and has the potential to facilitate malignant progression. This chapter provides a synopsis of hypoxia-regulated pathways implicated in the maintenance of cancer stem cells.

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Acknowledgments

The authors are grateful to the members of the Yun Laboratory for their contribution to the understanding of tumor hypoxia and stemness regulation. The authors also thank Lisa Cabral for excellent assistance in the preparation of this manuscript. Z.Y. is supported in part by R01CA125021 and R01CA148996 from the National Institutes of Health, Bethesda, MD, USA.

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Authors and Affiliations

  1. Department of Therapeutic Radiology, Yale School of Medicine, 208040, New Haven, 06520-8040, CT, USA

    Zhong Yun Ph.D. & Qun Lin

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  1. Zhong Yun Ph.D.
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  2. Qun Lin
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Correspondence to Zhong Yun Ph.D. .

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Editors and Affiliations

  1. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

    Constantinos Koumenis

  2. Cancer Research, Gray Institute for Radiation Oncology, Oxford, United Kingdom

    Ester Hammond

  3. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA

    Amato Giaccia

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Yun, Z., Lin, Q. (2014). Hypoxia and Regulation of Cancer Cell Stemness. In: Koumenis, C., Hammond, E., Giaccia, A. (eds) Tumor Microenvironment and Cellular Stress. Advances in Experimental Medicine and Biology, vol 772. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5915-6_2

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