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Regulation of Angiogenesis by Hypoxia-Inducible Factors

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

Abstract

In the years since the identification of hypoxia-inducible factors (HIFs), it has been well established that HIFs regulate angiogenic genes, such as vascular endothelial growth factor. HIFs play essential roles in embryonic vascular development. Recent studies have demonstrated that HIFs can influence the adult vascular system, not only in neovascularization but also in angiogenesis in pathological conditions. In this chapter, oxygen-dependent and novel oxygen-­independent regulatory systems of HIF-αs are reviewed. Hypoxia-associated factor regulates HIF-1α and HIF-2α reversely. Int6-silencing stabilizes HIF-2α and functional vessel formation. HIFs can be therapeutic targets in both anti-­angiogenic and angiogenic therapy. The new findings have implications for the development of therapies for ischemic disease.

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Author information

Authors and Affiliations

  1. Molecular Medical Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-Ku, Tokyo, 156-8506, Japan

    Hideki Hayakawa & Futoshi Shibasaki

Authors
  1. Hideki Hayakawa
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  2. Futoshi Shibasaki
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Correspondence to Futoshi Shibasaki .

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Editors and Affiliations

  1. Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, 4301 W Markham, Little Rock, 72205, Arkansas, USA

    Jawahar L. Mehta

  2. Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, 351 Tache Avenue, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Hayakawa, H., Shibasaki, F. (2013). Regulation of Angiogenesis by Hypoxia-Inducible Factors. In: Mehta, J., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5857-9_6

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