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GER in Lung Transplantation

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Gastroesophageal Reflux and the Lung

Part of the book series: Respiratory Medicine ((RM,volume 2))

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Abstract

Abnormal gastroesophageal reflux (GER) is present in a substantial number of patients with advanced lung disease due to a variety of causes and is especially prevalent in patients with pulmonary fibrosis or bronchiectasis. GER and microaspiration of refluxed gastroduodenal secretions have been linked to posttransplant lung allograft complications especially bronchiolitis obliterans syndrome (BOS) in which obliterative bronchiolitis (OB) can lead to progressive allograft dysfunction and loss. A considerable body of literature has linked abnormal GER to BOS, and strategies to prevent reflux may lessen the risk for developing BOS as well as diminish the risk of progression when BOS associated with abnormal GER occurs and leads to allograft functional impairment. This chapter will discuss the potential role of abnormal GER and microaspiration in the development of posttransplant allograft dysfunction and examine potential strategies to manage transplant recipients with evidence of abnormal GER.

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Authors and Affiliations

  1. Department of Medicine, University of Wisconsin School of Medicine and Public Health, K4/910 CSC, 600 Highland Avenue, Madison, WI, 53792-9988, USA

    Keith C. Meyer M.D., M.S.

  2. Department of Surgery, Division of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA

    James D. Maloney M.D.

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  1. Keith C. Meyer M.D., M.S.
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Correspondence to Keith C. Meyer M.D., M.S. .

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  1. , Department of Medicine, University of Wisconsin School of Medici, 600 Highland Avenue, Madison, 53792-9988, Wisconsin, USA

    Keith C. Meyer

  2. , Division of Pulmonary and Critical Care, University of Washington School of Medic, Campus Box 356175, Seatt;e, 98195, Washington, USA

    Ganesh Raghu

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Meyer, K.C., Maloney, J.D. (2012). GER in Lung Transplantation. In: Meyer, K., Raghu, G. (eds) Gastroesophageal Reflux and the Lung. Respiratory Medicine, vol 2. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5502-8_11

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