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Increased Risk of Diabetes due to Obesity: Does Chronodisruption Play a Role?

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Chronobiology and Obesity

Abstract

The prevalence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic proportions. The pathophysiology of T2DM is complex and involves insulin resistance, pancreatic β-cell dysfunction and visceral adiposity. Although it has been known for quite some time that a disruption of biological rhythms (as happens with shift work) increases the risk of developing obesity, insulin resistance and T2DM, more recent genomic evidence has further spiked the interest for the involvement of circadian rhythms (and their disruption) in the development of diabetes. In this chapter, we will start with an overview of the way in which glucose metabolism and the basal rhythm in plasma glucose concentrations and insulin sensitivity are regulated, after which we will discuss how a disruption of daily rhythms or a disruption of clock elements, may contribute to the development of insulin resistance.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands

    Susanne E. la Fleur Ph.D. & Andries Kalsbeek Ph.D.

  2. Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, 1105 BA, Amsterdam, The Netherlands

    Andries Kalsbeek Ph.D.

Authors
  1. Susanne E. la Fleur Ph.D.
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  2. Andries Kalsbeek Ph.D.
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Corresponding author

Correspondence to Susanne E. la Fleur Ph.D. .

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Editors and Affiliations

  1. , Department of Physiology, University of Murcia, Avda. Teniente Flomesta, Murcia, 30100, Spain

    Marta Garaulet

  2. Tufts University School of Medicine, Washington Street 711, Boston, 02115, USA

    Jose M. Ordovás

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la Fleur, S.E., Kalsbeek, A. (2013). Increased Risk of Diabetes due to Obesity: Does Chronodisruption Play a Role?. In: Garaulet, M., Ordovás, J. (eds) Chronobiology and Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5082-5_7

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