Abstract
A novel cancer treatment method is being designed using a combination of iron oxide (Fe3O4) nanoparticles (IONPs) and Pluronic F-127 (PF127). IONPs have been used for heating tumors via an alternating electromagnetic (AEM) field. PF127 is a polymer possessing thermo-reversible and concentration-dependent gelation properties in aqueous solutions. PF127, as a gel, is an attractive drug delivery vehicle due to its zero-order drug release property. The combination of IONPs and PF127 would allow both short-term, tumor-specific, hyperthermic treatment, and long-term sustained drug delivery. As a preliminary study, the gelling and heating properties of IONPs/PF127 mixtures were investigated: 18% (w/w) PF127 was found to be ideal for our purpose because it gels at 28.0°C, i.e., it would be injectable at room temperature (20–25°C) and forms gel upon injection into the body (37°C). IONPs in PF127 showed little effect on gelation temperatures. The heating performance of IONPs in PF127 slightly, but linearly decreased with PF127. In the IONP concentration range of 0.01–0.05% (w/v) mixed with PF127 at 18% (w/w), the heating performance increased linearly with the increase in IONP concentration.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Miyazaki S, Ohkawa Y, Takada M et al (1992) Anti-tumor effect of Pluronic F-127 containing Mitomycin C on Saroma 180 ascites tumor. Chem Pharm Bull 40:2224–2226
Hatefi A, Amsden B (2002) Review: biodegradable injectable in situ forming drug delivery systems. Release 80:9–28
Escobar-Chávez JJ, López-Cervantes M, Naïk A et al (2006) Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm Sci 9:339–358
Rapoport N (2007) Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci 32:962–990
Jeong B, Kim SW, Bae YH (2002) Thermosensitive sol-gel reversible hydrogels. Adv Drug Del Rev 54:37–51
Cabana A, Ait-Kadi A, Juhász J (1997) Study of the gelation process of polyethylene oxide-polypropylene oxide-polyethylene oxide copolymer (Poloxamer 407) aqueous solutions. J Colloid Interface Sci 190:307–312
Chung HJ, Go DH, Bae JW et al (2005) Synthesis and characterization of Pluronic® grafted chitosan copolymer as a novel injectable biomaterial. Curr Appl Phys 5:485–488
Lenaerts V, Triqueneaux C, Quartern M et al (1987) Temperature-dependent rheological behavior of Pluronic F-127 aqueous solutions. Int J Pharm 39:121–127
Anderson BC, Pandit NK, Mallapragada SK (2001) Understanding drug release from poly (ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) gels. J Control Release 70:157–167
Jeong B, Bae YH, Kim SW (2000) Drug release from biodegradable injectable thermosensitive hydrogel of PEF-PLGA-PEG triblock copolymers. J Control Release 63:155–163
Zhang L, Parsons DL, Navarre C et al (2002) Development and in-vitro evaluation of sustained release Poloxamer 407 (P407) gel formulations of ceftiofur. J Control Release 85:73–81
Moore T, Croy S, Mallapragada S et al (2000) Experimental investigation and mathematical modeling of Pluronic® F127 gel dissolution: drug release in stirred systems. J Control Release 67:191–202
Kaowumpai W, Koolpiruck D, Viravaidya K (2007) Development of a 3D mathematical model for a doxorubicin controlled release system using pluronic gel for breast cancer treatment. Proceedings of the World Academy of Science, Engineering and Technology December: 287–292
Xu X, Lee P (1993) Programmable drug delivery from an erodible association polymer system. Pharm Res 10:1144–1152
Hong YJ, Lee HY, Kim J (2009) Preparations and temperature-dependent release properties of Pluronic F-127 containing microcapsules prepared by a double emulsion technique. J Ind Eng Chem 15:758–762
El-Kamel AH (2002) In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system fortimolol maleate. Int J Pharm 241:47–55
Sanapala KK, Hewparakrama K, Kang KA (2009) Effect of AEM energy applicator configuration of magnetic nanoparticles mediated hyperthermia for breast cancer. Adv Exp Med Biol Oxygen Trans Tissue 32:143–147
Jin H, Kang KA (2007) Application of novel metal nanoparticles as optical/thermal agents in optical mammography and hyperthermia treatment for breast cancer. Adv Exp Med Biol Oxygen Trans Tissue 28:45–52
Acknowledgments
Special thanks go to Ms. Jianting Wang and Dr. Robert Lupitskyy for their help. The authors also thank BASF Global for their kind donation of PF127.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this paper
Cite this paper
Wang, S.Y., Liu, M.C., Kang, K.A. (2013). Magnetic Nanoparticles and Thermally Responsive Polymer for Targeted Hyperthermia and Sustained Anti-Cancer Drug Delivery. In: Welch, W.J., Palm, F., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXIV. Advances in Experimental Medicine and Biology, vol 765. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4989-8_44
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4989-8_44
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-4771-9
Online ISBN: 978-1-4614-4989-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)