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History of Diffuse Optical Spectroscopy of Human Tissue

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Optical Methods and Instrumentation in Brain Imaging and Therapy

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 3))

Abstract

Diffuse optical spectroscopy is a noninvasive method that uses low levels of near-infrared light to measure blood oxygenation in the brain. Over the last 35 years, the number of diffuse optical studies and the range of clinical and research applications have grown steadily. Compared to other neuroimaging methods to measure cerebral blood oxygenation, such as magnetic resonance imaging or positron emission tomography, diffuse optical imaging (DOI) is more cost effective and often uses small portable instrumentation. Wireless and bedside optical systems are currently produced commercially. The portability of these instruments has extended the use of optical methods into several unique applications including brain imaging in infants and children, studies of the brain during ambulatory tasks such as walking or balance, and interoperative brain assessments. This chapter will introduce the history and basic principles of DOI including discussion of the factors contributing to the optical properties of tissue, instrumentation, and an overview of applications of the technology.

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  1. Department of Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15219, USA

    Theodore J. Huppert

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    Steen J. Madsen

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Huppert, T.J. (2013). History of Diffuse Optical Spectroscopy of Human Tissue. In: Madsen, S. (eds) Optical Methods and Instrumentation in Brain Imaging and Therapy. Bioanalysis, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4978-2_2

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