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Mood Disorders and Immunity

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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders

Abstract

Depression is a common comorbid condition in substance abuse disorders. In particular, comorbidity between alcoholism and depression occurs with extremely high prevalence in the general population. Early studies investigating this dual diagnosis issue reported alcohol abuse to occur in almost a quarter of patients with affective disorders [1, 2]. Prevalence rises as high as 32 % if other substance abuse disorders are included [2]. These findings made it clear that enormous challenges lie ahead in tracing the individual etiology of substance abuse and depression, let alone their interaction. Clearly, this dilemma was to produce further difficulties in providing adequate and appropriate treatment for sufferers.

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Acknowledgments

This work was supported by National Institutes of Health grant RO1 AG029573 to Keith W. Kelley.

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Authors and Affiliations

  1. Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana-Champaign, 227 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL, 61801, USA

    Adam K. Walker, Robert Dantzer & Keith W. Kelley Ph.D.

  2. Department of Medical Pathology, University of Illinois at Urbana-Champaign, 227 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL, 61801, USA

    Robert Dantzer & Keith W. Kelley Ph.D.

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  1. Adam K. Walker
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  2. Robert Dantzer
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  3. Keith W. Kelley Ph.D.
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Correspondence to Keith W. Kelley Ph.D. .

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Editors and Affiliations

  1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Changhai Cui

  2. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Lindsey Grandison

  3. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Antonio Noronha

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Walker, A.K., Dantzer, R., Kelley, K.W. (2013). Mood Disorders and Immunity. In: Cui, C., Grandison, L., Noronha, A. (eds) Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4729-0_6

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