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Overview of Nonclassical Cannabinoid Receptors

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endoCANNABINOIDS

Part of the book series: The Receptors ((REC,volume 24))

Abstract

The vast majority of the biological effects of plant-derived cannabinoids and their endogenous mammalian counterparts are mediated by CB1 and CB2 receptors, G protein-coupled receptors (GPCRs) identified by molecular cloning in the early 1990s. Since that time, there has been a growing body of pharmacological evidence indicating the existence of additional molecular targets for cannabinoids. This chapter overviews the nonclassical targets thought to be present in vascular endothelium, central nervous system and, possibly, other tissues, with emphasis on GPCRs. The possible relationship with orphan GPCR is discussed in greater detail, particularly GPR18, GPR55, GPR92, GPR119, and other GPCRs, which are reportedly activated by various endogenous, plant-derived, and synthetic cannabinoids.

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Acknowledgments

Work from the authors’ laboratory has been supported by the Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. We thank Dr. Laszlo Offertáler for his contribution to myograph experiments. Dr. Grzegorz Godlewski dedicates the chapter to his mother Romualda Godlewska.

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  1. Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA

    Grzegorz Godlewski & George Kunos

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  1. Grzegorz Godlewski
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  1. , Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140, Pennsylvania, USA

    Mary E. Abood

  2. National Institutes of Health, Division of Basic Neuroscience and Behav, National Institute on Drug Abuse, 6001 Executive Blvd, Bethesda, 20892, Maryland, USA

    Roger G Sorensen

  3. , Pharmacology and Psychiatry and Behavior, University of Washington, Box 357280, Seattle, 98195, Washington, USA

    Nephi Stella

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Godlewski, G., Kunos, G. (2013). Overview of Nonclassical Cannabinoid Receptors. In: Abood, M., Sorensen, R., Stella, N. (eds) endoCANNABINOIDS. The Receptors, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4669-9_1

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