Abstract
The circulating tumor cell (CTC) test is used to evaluate the condition of breast cancer patients by counting the number of cancer cells in peripheral blood samples. Although microfluidic systems to detect or separate cells using the inertial migration effect may be applied to this test, the hydrodynamic forces acting on cancer cells are incompletely understood. In this chapter, we explain the inertial migration of cancer cells in microchannels. We also explain fabrication techniques of microchannels used in the experiments. By measuring the cell migration probability, we examined the effects of cell deformability and variations in cell size on the inertial migration of cancer cells. The results clearly illustrate that cancer cells can migrate towards equilibrium positions in the similar manner with rigid spheres. These results will be important for the design of microfluidic devices for the CTC test.
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Acknowledgments
This study was supported by Grants-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science. We also acknowledge support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre.”
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Tanaka, T. et al. (2013). Inertial Migration of Cancer Cells in a Microfluidic Device. In: Collins, M., Koenig, C. (eds) Micro and Nano Flow Systems for Bioanalysis. Bioanalysis, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4376-6_2
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DOI: https://doi.org/10.1007/978-1-4614-4376-6_2
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