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Virus-Induced Models for Type 1 Diabetes in Mice

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Diabetes and Viruses

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Abstract

Epidemiological and experimental data strongly suggest that type 1 ­diabetes occurs as a detrimental combination of genetic predisposition and environmental triggering factors. Viruses have been implicated in the etiology of type 1 diabetes as environmental triggers due to epidemiological association as well as by direct isolation from pancreatic type 1 diabetes patients. The concept of virus-induced type 1 diabetes has been used as an experimental basis in several mouse models. Studies are reviewed on how virus-induced animal models have helped to understand the mechanisms of the pathogenesis of autoimmune-mediated diabetes. We intend to review how such findings obtained from animal models have helped to design novel therapeutic interventions for type 1 diabetes.

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Authors and Affiliations

  1. Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital, Frankfurt am Main, Germany

    Urs Christen Ph.D.

  2. La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA

    Matthias G. von Herrath M.D.

Authors
  1. Urs Christen Ph.D.
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  2. Matthias G. von Herrath M.D.
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Corresponding author

Correspondence to Urs Christen Ph.D. .

Editor information

Editors and Affiliations

  1. Queen Mary's School of Medicine and Dent, Centre for Diabetes & Metabolic Medicine, Institute of Cell & Molecular Science, n/a, London, E1 2AT, United Kingdom

    Keith Taylor

  2. Tampere University Hospital, Department of Virology, University of Tampere, n/a, Tampere, 33520, Finland

    Heikki Hyöty

  3. University of Insubria & Ospedale di Cir, Varese, Italy

    Antonio Toniolo

  4. University College London Medical School, n/a, London, NW3 2PF, United Kingdom

    Arie J. Zuckerman

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Christen, U., von Herrath, M.G. (2013). Virus-Induced Models for Type 1 Diabetes in Mice. In: Taylor, K., Hyöty, H., Toniolo, A., Zuckerman, A. (eds) Diabetes and Viruses. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4051-2_25

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