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Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms

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Neoplastic Diseases of the Blood

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Abstract

The hematopoietic growth factors (HGFs) are a group of naturally occurring glycoproteins required for the survival, proliferation, and differentiation of hematopoietic cells. Their effects are mediated by high-affinity binding to specific receptors on their hematopoietic target cells. The isolation, purification, cloning, and manufacture of HGFs has permitted their clinical use, originally to correct cytopenias caused by deficiency of specific growth factors, and subsequently in numerous other settings. Recombinant HGFs are used in the treatment of patients with hematologic malignancies to improve disease and treatment-related cytopenias and to mobilize hematopoietic stem cells from the marrow into the peripheral blood from where they can be harvested for autologous and allogeneic hematopoietic cell transplantation. This chapter will focus on the biology and use of the clinically important recombinant HGFs in patients with hematologic malignancies. Those HGFs which are employed clinically will be individually discussed, followed by a description of their application in specific diseases and clinical settings.

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Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, The Ohio State University, B-311 Starling Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA

    Belinda R. Avalos M.D.

  2. Department of Hematological Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Ave R35, Cleveland, OH, 44195, USA

    Edward A. Copelan M.D.

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  1. Belinda R. Avalos M.D.
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  1. Beth Israel Hospital, Cancer Center, St. Lukes-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Peter H. Wiernik

  2. , Department of Hematology, Imperial College of London, Du Cane Road 150, London, W12 0NN, United Kingdom

    John M. Goldman

  3. Continuum Cancer Centers, Department of Medicine, St. Luke's-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Janice P. Dutcher

  4. , Division of Hematology, Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Robert A. Kyle

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Avalos, B.R., Copelan, E.A. (2013). Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms. In: Wiernik, P., Goldman, J., Dutcher, J., Kyle, R. (eds) Neoplastic Diseases of the Blood. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3764-2_60

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