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Basic Cardiac Development: The Heart and Its Electrical Components

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Ontogeny and Phylogeny of the Vertebrate Heart

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Abstract

The heart, an organ simple in function and design, is a muscular pump ensuring the constant systemic blood flow supplying oxygen and nutrients to the body’s organs and relieving them of waste products. Although this description is instructive, it is in no way a reflection of the complex molecular processes that have gone into its correct development. This chapter sets out to present the reader with the very basics for understanding the one of the earliest phases of embryology. Starting at the moment of fertilization, the proceeding anatomical and key molecular events that lead to the correct positioning and development of the four-chambered mammalian heart are dealt with in a concise and understandable manner. Particular attention is paid to the development of the heart’s electrical system and the subcomponents essential to the correct pacing and rapid conduction of the electrical impulse that will ensure rhythmicity of the contracting atria and ventricles. Further reference reading is offered throughout the chapter for readers with a more detailed interest in the processes presented here.

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Authors and Affiliations

  1. Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands

    L. Y. E. Wong, A. F. Moorman & P. Barnett

Authors
  1. L. Y. E. Wong
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  2. A. F. Moorman
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  3. P. Barnett
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Correspondence to P. Barnett .

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Editors and Affiliations

  1. , Institute of Anatomy, Charles University, U nemocnice 3, Prague, 128 00, Czech Republic

    David Sedmera

  2. Fac. Science, Inst. Biological Sciences Zoofysiology, University of Aarhus, C. F. Moellers Allé, Aarhus C, 8000, Denmark

    Tobias Wang

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Wong, L.Y.E., Moorman, A.F., Barnett, P. (2012). Basic Cardiac Development: The Heart and Its Electrical Components. In: Sedmera, D., Wang, T. (eds) Ontogeny and Phylogeny of the Vertebrate Heart. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3387-3_8

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