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Dementia and Alzheimer Disease: Evidence-Based Neuroimaging

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Evidence-Based Neuroimaging Diagnosis and Treatment

Part of the book series: Evidence-Based Imaging ((Evidence-Based Imag.))

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Abstract

AD is a progressive neurodegenerative dementia. The pathological hallmarks of AD are accumulation of neurofibrillary tangles and senile plaques. The neurofibrillary pathology, which is associated with cognitive dysfunction, neuron, and synapse loss, involves the limbic cortex early in the disease course and extends to the neocortex as the disease progresses. In addition to the histopathological changes, there is a gradual loss of cholinergic innervation in AD, which has been the basis for cholinesterase inhibitor therapy.

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Authors and Affiliations

  1. Department of Radiology, University of Texas, Health Science Center at San Antonio, San Antonio, TX, 78229, USA

    Juan E. Gutierrez & Brian Eichinger

  2. Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN, 55902, USA

    Kejal Kantarci

Authors
  1. Juan E. Gutierrez
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  2. Brian Eichinger
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  3. Kejal Kantarci
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Corresponding author

Correspondence to Juan E. Gutierrez .

Editor information

Editors and Affiliations

  1. Division of Neuroradiology-Neuroimaging, Department of Radiology, Miami Children’s Hospital, Miami, FL, USA

    L. Santiago Medina

  2. Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA

    L. Santiago Medina

  3. Former Lecturer in Radiology, Harvard Medical School, Boston, MA, USA

    L. Santiago Medina

  4. Department of Radiology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA

    Pina C. Sanelli

  5. Department of Radiology, Harborview Medical Center, University of Washington, Seattle, WA, USA

    Jeffrey G. Jarvik

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Gutierrez, J.E., Eichinger, B., Kantarci, K. (2013). Dementia and Alzheimer Disease: Evidence-Based Neuroimaging. In: Medina, L.S., Sanelli, P.C., Jarvik, J.G. (eds) Evidence-Based Neuroimaging Diagnosis and Treatment. Evidence-Based Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3320-0_17

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  • DOI: https://doi.org/10.1007/978-1-4614-3320-0_17

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