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Endogenous Remyelination in the CNS

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Myelin Repair and Neuroprotection in Multiple Sclerosis

Abstract

In striking contrast to the generally inadequate attempts at regeneration that follows damage to neuronal elements, the sequela to CNS demyelination is often a robust regenerative process called remyelination. In this chapter, we (1) review current knowledge on the biology of remyelination, including the cells and molecular signals involved; (2) describe when remyelination occurs and when and why it fails, including the consequences of its failure; and (3) discuss approaches for enhancing endogenous remyelination therapeutically in demyelinating diseases.

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Authors and Affiliations

  1. Wellcome Trust and MRC, Cambridge Stem Cell Institute, and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK

    Robin J. M. Franklin & Chao Zhao

  2. Départment de Neurologie et CR-ICM, AP-HP, Inserm 975, UPMC, Hôpital de la Salpêtrière, 75013, Paris, France

    Catherine Lubetzki

  3. MRC Centre for Regenerative Medicine/ Scottish Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK

    Charles ffrench-Constant

  4. University of Edinburgh Centre for Translational Research, Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

    Charles ffrench-Constant

Authors
  1. Robin J. M. Franklin
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  2. Chao Zhao
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  3. Catherine Lubetzki
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  4. Charles ffrench-Constant
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Correspondence to Robin J. M. Franklin .

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Editors and Affiliations

  1. School Veterinary Medicine, Dept. Medical Sciences, University of Wisconsin Madison, Linden Drive West 2015, Madison, 53706-1102, Wisconsin, USA

    Ian D. Duncan

  2. Wellcome Trust and MRC Cambridge Stem Ce, and Department of Veterinary Medicine, University Cambridge, Madingley Road, Cambridge, CB3 0ES, United Kingdom

    Robin J M Franklin

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Franklin, R.J.M., Zhao, C., Lubetzki, C., ffrench-Constant, C. (2013). Endogenous Remyelination in the CNS. In: Duncan, I., Franklin, R. (eds) Myelin Repair and Neuroprotection in Multiple Sclerosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2218-1_4

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