Skip to main content

Neurobiology of Learning and Memory

  • Reference work entry
Neuroscience in the 21st Century

Abstract

Memory is fundamental to human life. Qualitatively distinct types of memory enable us to change behavior in response to experience, to acquire and use a repository of knowledge, to recollect events from the past, and to plan for the future. In many respects, memory defines human individuality, as the memories of one person are necessarily different from those of another. Where they overlap, as in the shared memories of a community or a nation, they form a cultural memory that is often ritualized into various art forms. The use of memory is changing, with a great deal of human knowledge now externalized and then sought on demand through the use of search engines on the internet. Nonetheless, the loss of memory remains greatly feared, perhaps because it is recognized that loss of private episodic memories would undermine the sense of self. Moreover, the inability to recollect events and episodes can develop from a minor irritation to a condition that undermines normal daily existence.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 1,699.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Further Reading

  • Buzsaki G (2004) Large scale recording of neuronal ensembles. Nat Neurosci 7:447

    Article  Google Scholar 

  • Corkin S, Amaral DG, Gilberto Gonzalez R, Johnson KA, Hyman BT (1997) H. M’.s medial temporal lobe lesion: findings from magnetic resonance imaging. J Neurosci 17:3964–3979

    PubMed  CAS  Google Scholar 

  • Deisseroth K (2011) Optogenetics. Nat Methods 8:26–29

    Article  PubMed  CAS  Google Scholar 

  • Dudai Y (1996) Consolidation: fragility on the road to the engram. Neuron 17:367–370

    Article  PubMed  CAS  Google Scholar 

  • Eichenbaum H, Fortin NJ (2009) The neurobiology of memory-based predictions. Phil Trans R Soc B 364:1183–1191

    Article  PubMed  Google Scholar 

  • Frey U, Morris RGM (1998) Synaptic tagging: implications for late maintenance of hippocampal long- term potentiation. Trends Neurosci 21:181–188

    Article  PubMed  CAS  Google Scholar 

  • Govindarajan A, Israely I, Huang SY, Tonegawa S (2011) The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP. Neuron 69(1):134

    Article  Google Scholar 

  • Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030–1038

    Article  PubMed  CAS  Google Scholar 

  • Mishkin M, Suzuki WA, Gadian DG, Vargha_Khadem F (1997) Hierarchical organization of cognitive memory. Philos Trans R Soc Lond B Biol Sci 352:1461–1467

    Article  PubMed  CAS  Google Scholar 

  • Morris RGM (2006) Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas. Eur J Neurosci 23:2829–2846

    Article  PubMed  CAS  Google Scholar 

  • Moser E, Kropff E, Moser M (2008) Place cells, grid cells, and the brain’s spatial representation system. Annu Rev Neurosci 31:69–89

    Article  PubMed  CAS  Google Scholar 

  • Nakazawa K, McHugh TJ, Wilson MA, Tonegawa S (2004) NMDA receptors, place cells and hippocampal spatial memory. Nat Rev Neurosci 5:361–372

    Article  PubMed  CAS  Google Scholar 

  • O’Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Clarendon, Oxford

    Google Scholar 

  • Redondo RL, Morris RGM (2011) Making memories last: the synaptic tagging and capture hypothesis. Nat Rev Neurosci 12:17–30

    Article  PubMed  CAS  Google Scholar 

  • Squire LR, Stark CE, Clark RE (2004) The medial temporal lobe. Annu Rev Neurosci 27:279–306

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard Morris .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this entry

Cite this entry

Morris, R. (2013). Neurobiology of Learning and Memory. In: Pfaff, D.W. (eds) Neuroscience in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1997-6_81

Download citation

Publish with us

Policies and ethics