Abstract
The chondromyxoid fibroma is a rare beningn metaphyseal tumor that mainly affects children and adolescents. It is sometimes confused with enchondromas and condroblastomas, but it can be differentiated by histological analysis since it is composed of a mixture of chondroid, myxoid, and fibrous tissues. Clinically it can manifest with moderate pain and swelling in the case of large tumors. In the X-ray it appears as a lobulated, osteolyic lesion located eccentrically in the metaphysis of the bone. Surgical treatment is indicated in case of symptomatic lesions and at risk of pathological fracture, and consists of intralesional resection and filling the defect with bone graft.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lersundi A, Mankin HJ, Mourikis A, Hornicek FJ. Chondromyxoid fibroma: a rarely encountered and puzzling tumor. Clin Orthop Relat Res. October 2005;439:171–5.
Sharma H, Jane MJ, Reid R. Chondromyxoid fibroma of the foot and ankle: 40 years’ Scottish bone tumour registry experience. Int Orthop. 2006;30(3):205–9.
Dahlin DC, Wells AH, Henderson ED. Chondromyxoid fibroma of bone; report of two cases. J Bone Joint Surg Am 1953;35-A(4):831–834.
Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone; a distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol (Chic). 1948;45(4):541–51.
Zustin J, Akpalo H, Gambarotti M, et al. Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: An immunohistochemical study. Am J Pathol. 2010;177(3):1072–8.
Yasuda T, Nishio J, Sumegi J, et al. Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. Mod Pathol 2009;22(11):1499–1506.
Wu CT, Inwards CY, O’Laughlin S, Rock MG, Beabout JW, Unni KK. Chondromyxoid fibroma of bone: A clinicopathologic review of 278 cases. Hum Pathol. 1998;29(5):438–46.
Dahlin DC. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. Cancer. 1956;9(1):195–203.
Romeo S, Eyden B, Prins FA, Briaire-de Bruijn IH, Taminiau AH, Hogendoorn PC. TGF-beta1 drives partial myofibroblastic differentiation in chondromyxoid fibroma of bone. J Pathol. 2006;208(1):26–34.
Park HR, Park YK, Jang KT, Unni KK. Expression of collagen type II, S100B, S100A2 and osteocalcin in chondroblastoma and chondromyxoid fibroma. Oncol Rep. 2002;9(5):1087–91.
Dürr HR, Lienemann A, Nerlich A, Stumpenhausen B, Refior HJ. Chondromyxoid fibroma of bone. Arch Orthop Trauma Surg. 2000;120(1–2):42–47.
Rahimi A, Beabout JW, Ivins JC, Dahlin DC. Chondromyxoid fibroma: a clinicopathologic study of 76 cases. Cancer. 1972;30(3):726–36.
Armah HB, McGough RL, Goodman MA, et al. Chondromyxoid fibroma of rib with a novel chromosomal translocation: A report of four additional cases at unusual sites. Diagn Pathol. 2007;2:44.
Baker AC, Rezeanu L, O’Laughlin S, Unni K, Klein MJ, Siegal GP. Juxtacortical chondromyxoid fibroma of bone: a unique variant: a case study of 20 patients. Am J Surg Pathol. 2007;31(11):1662–1668.
Yamaguchi T, Dorfman HD. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Skeletal Radiol. 1998;27(10):559–64.
Unni KK, Inwards CY. Chondromyxoid fibroma. In: Unni KK, Inwards CY, editors. Dahlin’s bone tumors, 6th edn. Philadelphia, PA: Wolters Kluwer, Lippincott Williams & Wilkins; 2010. p. 50–59.
Hasegawa T, Seki K, Yang P, et al. Differentiation and proliferative activity in benign and malignant cartilage tumors of bone. Hum Pathol. 1995;26(8):838–45.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer-Verlag London Ltd., part of Springer Nature
About this chapter
Cite this chapter
Poitout, D.G. (2021). Chondromyxoid Fibroma. In: Paulos, J., Poitout, D.G. (eds) Bone Tumors. Springer, London. https://doi.org/10.1007/978-1-4471-7501-8_8
Download citation
DOI: https://doi.org/10.1007/978-1-4471-7501-8_8
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-7499-8
Online ISBN: 978-1-4471-7501-8
eBook Packages: MedicineMedicine (R0)