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Systemic Inflammatory Response to Cardiopulmonary Bypass in Pediatric Patients and Related Strategies for Prevention

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Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

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Abstract

Cardiopulmonary bypass in pediatric patients is associated with generalized activation of both innate and acquired immunity. The systemic inflammatory response occurs in response to multiple nonphysiologic stimuli. Activation of the inflammatory response involves an intricate cascade which results in pronounced amplification that affects nearly every end-organ system. These processes have a direct role in commonly encountered postoperative complications and can lead to significant morbidity following repair of congenital heart defects. This chapter will discuss the systemic inflammatory response related to cardiopulmonary bypass and measures that attempt to modulate this phenomenon.

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Author information

Authors and Affiliations

  1. Department of Cardiovascular Surgery, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA

    Raghav Murthy

  2. Division of Pediatric Cardiac Surgery and the Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA

    Tara Karamlou

  3. Pediatric Cardiac Surgery, Driscoll Children’s Hospital, Corpus Christi, TX, USA

    Ross M. Ungerleider

Authors
  1. Raghav Murthy
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  2. Tara Karamlou
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  3. Ross M. Ungerleider
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Corresponding author

Correspondence to Tara Karamlou .

Editor information

Editors and Affiliations

  1. Children’s Hospital Colorado University of Colorado Denver, School of, Aurora, CO, USA

    Eduardo M. da Cruz

  2. Children's Hospital Colorado University of Colorado School of Medicin, Aurora, CO, USA

    Dunbar Ivy

  3. Department of Cardiac Surgery, German Pediatric Heart Center, Sankt Augustin, Germany

    Viktor Hraska

  4. Pediatric Cardiac Surgery, Children's Hospital Colorado University of Colorado, Aurora, CO, USA

    James Jaggers

Section Editor information

  1. Corpus Christi, USA

    Ross M. Ungerleider

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Murthy, R., Karamlou, T., Ungerleider, R.M. (2020). Systemic Inflammatory Response to Cardiopulmonary Bypass in Pediatric Patients and Related Strategies for Prevention. In: da Cruz, E., Ivy, D., Hraska, V., Jaggers, J. (eds) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer, London. https://doi.org/10.1007/978-1-4471-4999-6_77-2

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  • DOI: https://doi.org/10.1007/978-1-4471-4999-6_77-2

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