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Simple Transposition of the Great Arteries

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Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

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Abstract

Transposition of the great arteries (TGA) is one of the more common cyanotic congenital heart defects with an incidence of about 300 per million live births. In TGA, the ventriculo-arterial connection is reversed such that the majority of the aorta arises from the right ventricle, while the majority of the pulmonary artery arises from the left ventricle. This defect is incompatible with long-term survival without surgical correction. Since the arterial switch procedure was introduced in the 1970s, early anatomic and physiologic repair has become the standard of care for these children with an expectation of excellent long-term outcomes for the majority.

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References

  1. Baillie M (1974) The morbid anatomy in some of the Most important parts of the human body. CA Cancer J Clin 24(1):49–56

    Article  Google Scholar 

  2. Farre JR (1814) Pathological researches on Malformations of the human heart. Longman, Hurst, Rees, Orme, and Brown, Paternoster-Row, London. https://archive.org/stream/pathologicalrese00farr#page/n9/mode/2up. Accessed June 2018

    Google Scholar 

  3. Peacock TB (1867) Art. XXVII. – On Malformations of the human heart, etc., with original cases and illustrations. Am J Med Sci 53(108):515–519

    Article  Google Scholar 

  4. The Hunterian Lectures on Malformations of the Heart (1909) Lancet 174(4485):433–436

    Article  Google Scholar 

  5. Hoffman JIE, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39(12):1890–1900

    Article  PubMed  Google Scholar 

  6. van der Linde D, Konings EEM, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJM et al (2011) Birth prevalence of congenital heart disease worldwide. A Syst Rev Metaanal 58(21):2241–2247

    Google Scholar 

  7. Abu-Sulaiman RM, Subaih B (2004) Congenital heart disease in infants of diabetic mothers: echocardiographic study. Pediatr Cardiol 25(2):137–140

    Article  CAS  PubMed  Google Scholar 

  8. Jenkins KJ, Correa A, Feinstein JA, Botto L, Britt AE, Daniels SR et al (2007) Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on cardiovascular disease in the young: endorsed by the American Academy of Pediatrics. Circulation 115(23):2995–3014

    Article  PubMed  Google Scholar 

  9. Snijder CA, Vlot IJ, Burdorf A, Obermann-Borst SA, Helbing WA, Wildhagen MF et al (2012) Congenital heart defects and parental occupational exposure to chemicals. Hum Reprod 27(5):1510–1517

    Article  CAS  PubMed  Google Scholar 

  10. Loffredo CA (2001) Association of Transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides. Am J Epidemiol 153(6):529–536

    Article  CAS  PubMed  Google Scholar 

  11. Muncke N (2003) Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation 108(23):2843–2850

    Article  CAS  PubMed  Google Scholar 

  12. Karkera JD, Lee JS, Roessler E, Banerjee-Basu S, Ouspenskaia MV, Mez J et al (2007) Loss-of-function mutations in growth differentiation Factor-1 (GDF1) are associated with congenital heart defects in humans. Am J Hum Genet 81(5):987–994

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Goldmuntz E, Bamford R, Karkera JD, dela Cruz J, Roessler E, Muenke M (2002) CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle. Am J Hum Genet 70(3):776–780

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Amati F, Diano L, Campagnolo L, Vecchione L, Cipollone D, Bueno S et al (2010) Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist. BMC Genomics 11(1):497

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Huang JB, Liu YL, Sun PW, Lv XD, Du M, Fan XM (2010) Molecular mechanisms of congenital heart disease. Cardiovasc Pathol 19(5):e183–e193

    Article  CAS  PubMed  Google Scholar 

  16. De Luca A, Sarkozy A, Consoli F, Ferese R, Guida V, Dentici ML et al (2010) Familial transposition of the great arteries caused by multiple mutations in laterality genes. Heart 96(9):673–677

    Article  PubMed  Google Scholar 

  17. Liebman J, Cullum L, Belloc NB (1969) Natural history of transposition of the great arteries: anatomy and birth and death characteristics. Circulation 40(2):237–262

    Article  CAS  PubMed  Google Scholar 

  18. Jaggers JJ, Cameron DE, Herlong JR, Ungerleider RM (2000) Congenital heart surgery nomenclature and database project: transposition of the great arteries. Ann Thorac Surg 69(3):205–235

    Article  Google Scholar 

  19. Van Praagh R (1984) Diagnosis of complex congenital heart disease: morphologic-anatomic method and terminology. Cardiovasc Intervent Radiol 7(3–4):115–120

    Article  PubMed  Google Scholar 

  20. Bartram U, Wirbelauer J, Speer CP (2005) Heterotaxy syndrome – asplenia and polysplenia as indicators of visceral malposition and complex congenital heart disease. Neonatology 88(4):278–290

    Article  Google Scholar 

  21. Sim EKW, van Son JAM, Edwards WD, Julsrud PR, Puga FJ (1994) Coronary artery anatomy in complete transposition of the great arteries. Ann Thorac Surg 57(4):890–894

    Article  CAS  PubMed  Google Scholar 

  22. Li J, Tulloh RM, Cook A, Schneider M, Ho SY, Anderson RH (2000) Coronary arterial origins in transposition of the great arteries: factors that affect outcome. A morphological and clinical study. Heart 83(3):320–325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Gittenberger-de Groot A SUea (1983) Coronary arterial anatomy in transposition of the great arteries: a morphologic study. Pediatr Cardiol (Suppl 1):15–24

    Google Scholar 

  24. Gittenberger-de Groot AC, Koenraadt WMC, Bartelings MM, Bökenkamp R, DeRuiter MC, Hazekamp MG et al (2018) Coding of coronary arterial origin and branching in congenital heart disease: the modified Leiden convention. J Thorac Cardiovasc Surg 156(6):2260–2269

    Article  PubMed  Google Scholar 

  25. Newfeld EA, Paul MH, Muster AJ, Idriss FS (1974) Pulmonary vascular disease in complete transposition of the great arteries: a study of 200 patients. Am J Cardiol 34(1):75–82

    Article  CAS  PubMed  Google Scholar 

  26. Kumar A, Taylor GP, Sandor GG, Patterson MW (1993) Pulmonary vascular disease in neonates with transposition of the great arteries and intact ventricular septum. Heart 69(5):442–445

    Article  CAS  Google Scholar 

  27. Rivenes SM, Grifka RG, Feltes TF (1998) Development of advanced pulmonary vascular disease in D-transposition of the great arteries after the neonatal arterial switch operation. Tex Heart Inst J 25(3):201–205

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Huhta JC (2005) Evaluating the fetus with transposition. Cardiol Young 15(S1):88

    Article  PubMed  Google Scholar 

  29. Rasiah SV, Publicover M, Ewer AK, Khan KS, Kilby MD, Zamora J (2006) A systematic review of the accuracy of first-trimester ultrasound examination for detecting major congenital heart disease. Ultrasound Obstet Gynecol 28(1):110–116

    Article  CAS  PubMed  Google Scholar 

  30. Calderon J, Angeard N, Moutier S, Plumet M-H, Jambaqué I, Bonnet D (2012) Impact of prenatal diagnosis on neurocognitive outcomes in children with transposition of the Great Arteries. J Pediatr 161(1):94–98.e1

    Article  PubMed  Google Scholar 

  31. de Wahl Granelli A, Wennergren M, Sandberg K, Mellander M, Bejlum C, Inganas L et al (2009) Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39 821 newborns. BMJ 338(jan08 2):a3037-a

    Article  Google Scholar 

  32. Maeno YV, Kamenir SA, Sinclair B, van der Velde ME, Smallhorn JF, Hornberger LK (1999) Prenatal features of ductus arteriosus constriction and restrictive foramen Ovale in d-transposition of the great arteries. Circulation 99(9):1209–1214

    Article  CAS  PubMed  Google Scholar 

  33. Roofthooft MTR, Bergman KA, Waterbolk TW, Ebels T, Bartelds B, Berger RMF (2007) Persistent pulmonary hypertension of the newborn with transposition of the great arteries. Ann Thorac Surg 83(4):1446–1450

    Article  PubMed  Google Scholar 

  34. Rashkind WJ (1966) Creation of an atrial septal defect without thoracotomy. A palliative approach to complete transposition of the great arteries. JAMA 196(11):991–992

    Article  CAS  PubMed  Google Scholar 

  35. McQuillen PS (2006) Balloon atrial Septostomy is associated with preoperative stroke in neonates with transposition of the great arteries. Circulation 113(2):280–285

    Article  PubMed  Google Scholar 

  36. Petit CJ, Rome JJ, Wernovsky G, Mason SE, Shera DM, Nicolson SC et al (2009) Preoperative brain injury in transposition of the great arteries is associated with oxygenation and time to surgery, Not Balloon Atrial Septostomy. Circulation 119(5):709–716

    Article  PubMed  PubMed Central  Google Scholar 

  37. Applegate SE, Lim DS (2010) Incidence of stroke in patients with d-transposition of the great arteries that undergo balloon atrial septostomy in the university Healthsystem consortium clinical Data Base/resource manager. Catheter Cardiovasc Interv 76(1):129–131

    Article  PubMed  Google Scholar 

  38. Mukherjee D, Lindsay M, Zhang Y, Lardaro T, Osen H, Chang DC et al (2010) Analysis of 8681 neonates with transposition of the great arteries: outcomes with and without Rashkind balloon atrial septostomy. Cardiol Young 20(04):373–380

    Article  PubMed  Google Scholar 

  39. Senning A (1959) Surgical correction of transposition of the great vessels. Surgery 45(6):966–980

    CAS  PubMed  Google Scholar 

  40. Mustard WT (1964) Successful two-stage correction of transposition of the great vessels. Surgery 55:469–472

    CAS  PubMed  Google Scholar 

  41. Jatene AD, Fontes VF, Paulista PP, Souza LC, Neger F, Galantier M et al (1976) Anatomic correction of transposition of the great vessels. J Thorac Cardiovasc Surg 72(3):364–370

    Article  CAS  PubMed  Google Scholar 

  42. Lecompte Y, Zannini L, Hazan E, Jarreau MM, Bex JP, Tu TV et al (1981) Anatomic correction of transposition of the great arteries. J Thorac Cardiovasc Surg 82(4):629–631

    Article  CAS  PubMed  Google Scholar 

  43. El-Said G, Rosenberg HS, Mullins CE, Hallman GL, Cooley DA, McNamara DG (1972) Dysrhythmias after mustard’s operation for transposition of the great arteries. Am J Cardiol 30(5):526–532

    Article  CAS  PubMed  Google Scholar 

  44. Kramer H-H, Rammos S, Krogmann O, Nessler L, Böker S, Krian A et al (1991) Cardiac rhythm after Mustard repair and after arterial switch operation for complete transposition. Int J Cardiol 32(1):5–12

    Article  CAS  PubMed  Google Scholar 

  45. Martin RP, Qureshi SA, Ettedgui JA, Baker EJ, O’Brien BJ, Deverall PB et al (1990) An evaluation of right and left ventricular function after anatomical correction and intra-atrial repair operations for complete transposition of the great arteries. Circulation 82(3):808–816

    Article  CAS  PubMed  Google Scholar 

  46. Backer CL, Ilbawi MN, Ohtake S, DeLeon SY, Muster AJ, Paul MH et al (1989) Transposition of the great arteries: a comparison of results of the Mustard procedure versus the arterial switch. Ann Thorac Surg 48(1):10–14

    Article  CAS  PubMed  Google Scholar 

  47. Haas F, Wottke M, Poppert H, Meisner H (1999) Long-term survival and functional follow-up in patients after the arterial switch operation. Ann Thorac Surg 68(5):1692–1697

    Article  CAS  PubMed  Google Scholar 

  48. Lupinetti FM, Bove EL, Minich LL, Snider AR, Callow LB, Meliones JN et al (1992) Intermediate-term survival and functional results after arterial repair for transposition of the great arteries. J Thorac Cardiovasc Surg 103(3):421–427

    Article  CAS  PubMed  Google Scholar 

  49. Davis AM, Wilkinson JL, Karl TR, Mee RB (1993) Transposition of the great arteries with intact ventricular septum. Arterial switch repair in patients 21 days of age or older. J Thorac Cardiovasc Surg 106(1):111–115

    Article  CAS  PubMed  Google Scholar 

  50. Yacoub MH, Radley-Smith R (1978) Anatomy of the coronary arteries in transposition of the great arteries and methods for their transfer in anatomical correction. Thorax 33(4):418–424

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Koshiyama H, Nagashima M, Matsumura G, Hiramatsu T, Nakanishi T, Yamazaki K (2016) Arterial switch operation with and without coronary relocation for intramural coronary arteries. Ann Thorac Surg 102(4):1353–1359

    Article  PubMed  Google Scholar 

  52. Takeuchi S, Katogi T (1990) New technique for the arterial switch operation in difficult situations. Ann Thorac Surg 50(6):1000; discussion 1

    Article  CAS  PubMed  Google Scholar 

  53. Rudra HS, Mavroudis C, Backer CL, Kaushal S, Russell H, Stewart RD et al (2011) The arterial switch operation: 25-year experience with 258 patients. Ann Thorac Surg 92(5):1742–1746

    Article  PubMed  Google Scholar 

  54. Adhyapak SM, Mahala BK, Pujar SV, Shetty PK, Sharma R (2007) Impact of left ventricular function on early outcomes after arterial switch for D-transposition of great arteries with intact ventricular septum. Indian Heart J 59(2):137–141

    PubMed  Google Scholar 

  55. Seear MD, Scarfe JC, LeBlanc JG (2008) Predicting major adverse events after cardiac surgery in children. Pediatr Crit Care Med 9(6):606–611

    Article  PubMed  Google Scholar 

  56. Bhutta AT, Ford JW, Parker JG, Prodhan P, Fontenot EE, Seib PM et al (2007) Noninvasive cerebral oximeter as a surrogate for mixed venous saturation in children. Pediatr Cardiol 28(1):34–41

    Article  PubMed  Google Scholar 

  57. Mittnacht AJC (2010) Near infrared spectroscopy in children at high risk of low perfusion. Curr Opin Anaesthesiol 23(3):342–347

    Article  PubMed  Google Scholar 

  58. Hoffman TM, Wernovsky G, Atz AM, Kulik TJ, Nelson DP, Chang AC et al (2003) Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 107(7):996–1002

    Article  CAS  PubMed  Google Scholar 

  59. Gaynor JW (2003) The effect of modified ultrafiltration on the postoperative course in patients with congenital heart disease. Pediatr Card Surg Ann Semin Thorac Cardiovasc Surg 6(1):128–139

    Article  Google Scholar 

  60. Sarris GE, Chatzis AC, Giannopoulos NM, Kirvassilis G, Berggren H, Hazekamp M et al (2006) The arterial switch operation in Europe for transposition of the great arteries: a multi-institutional study from the European congenital heart surgeons association. J Thorac Cardiovasc Surg 132(3):633–639

    Article  PubMed  Google Scholar 

  61. Falcao G, Ulate K, Kouzekanani K, Bielefeld MR, Morales JM, Rotta AT (2008) Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. Pediatr Cardiol 29(3):628–636

    Article  PubMed  Google Scholar 

  62. Dibardino DJ, Allison AE, Vaughn WK, McKenzie ED, Fraser CD (2004) Current expectations for newborns undergoing the arterial switch operation. Ann Surg 239(5):588–598

    Article  PubMed  PubMed Central  Google Scholar 

  63. Hirsch JC, Gurney JG, Donohue JE, Gebremariam A, Bove EL, Ohye RG (2007) Hospital mortality for Norwood and arterial switch operations as a function of institutional volume. Pediatr Cardiol 29(4):713–717

    Article  PubMed  Google Scholar 

  64. Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG (2011) Thirty-year experience with the arterial switch operation. Ann Thorac Surg 92(3):973–979

    Article  PubMed  Google Scholar 

  65. Wong SH, Finucane K, Kerr AR, O’Donnell C, West T, Gentles TL (2008) Cardiac outcome up to 15 years after the arterial switch operation. Heart Lung Circ 17(1):48–53

    Article  PubMed  Google Scholar 

  66. Qamar ZA, Goldberg CS, Devaney EJ, Bove EL, Ohye RG (2007) Current risk factors and outcomes for the arterial switch operation. Ann Thorac Surg 84(3):871–879

    Article  PubMed  Google Scholar 

  67. Massin MM (1999) Midterm results of the neonatal arterial switch operation. A review. J Cardiovasc Surg (Torino) 40(4):517–522

    CAS  Google Scholar 

  68. Losay J, Touchot A, Serraf A, Litvinova A, Lambert V, Piot JD et al (2001) Late outcome after arterial switch operation for transposition of the great arteries. Circulation 104(suppl 1):I-121-I-6

    Article  Google Scholar 

  69. Prifti E, Crucean A, Bonacchi M, Bernabei M, Murzi B, Luisi SV et al (2002) Early and long term outcome of the arterial switch operation for transposition of the great arteries: predictors and functional evaluation. Eur J Cardiothorac Surg 22(6):864–873

    Article  PubMed  Google Scholar 

  70. Choi BS, Kwon BS, Kim GB, Bae EJ, Noh CI, Choi JY et al (2010) Long-term outcomes after an arterial switch operation for simple complete transposition of the great arteries. Korean Circ J 40(1):23

    Article  PubMed  PubMed Central  Google Scholar 

  71. Gorler H, Ono M, Thies A, Lunkewitz E, Westhoff-Bleck M, Haverich A et al (2011) Long-term morbidity and quality of life after surgical repair of transposition of the great arteries: atrial versus arterial switch operation. Interact Cardiovasc Thorac Surg 12(4):569–574

    Article  PubMed  Google Scholar 

  72. Bonnet D, Bonhoeffer P, Piechaud JF, Aggoun Y, Sidi D, Planche C et al (1996) Long-term fate of the coronary arteries after the arterial switch operation in newborns with transposition of the great arteries. Heart 76(3):274–279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Manso B, Castellote A, Dos L, Casaldáliga J (2010) Myocardial perfusion magnetic resonance imaging for detecting coronary function anomalies in asymptomatic paediatric patients with a previous arterial switch operation for the transposition of great arteries. Cardiol Young 20(04):410–417

    Article  CAS  PubMed  Google Scholar 

  74. Tobler D, Motwani M, Wald RM, Roche SL, Verocai F, Iwanochko RM et al (2014) Evaluation of a comprehensive cardiovascular magnetic resonance protocol in young adults late after the arterial switch operation for d-transposition of the great arteries. J Cardiovasc Magn Reson 16(1):98

    Article  PubMed  PubMed Central  Google Scholar 

  75. Legendre A, Losay J, Touchot-Kone A, Serraf A, Belli E, Piot JD et al (2003) Coronary events after arterial switch operation for transposition of the great arteries. Circulation 108(Suppl 1):Ii186-90

    PubMed  Google Scholar 

  76. El-Segaier M, Lundin A, Hochbergs P, Jögi P, Pesonen E (2010) Late coronary complications after arterial switch operation and their treatment. Catheter Cardiovasc Interv 76(7):1027–1032

    Article  PubMed  Google Scholar 

  77. Mavroudis C, Stewart RD, Backer CL, Rudra H, Vargo P, Jacobs ML (2011) Reoperative techniques for complications after arterial switch. Ann Thorac Surg 92(5):1747–1755

    Article  PubMed  Google Scholar 

  78. Tsuda T, Bhat AM, Robinson BW, Baffa JM, Radtke W (2015) Coronary artery problems late after arterial switch operation for transposition of the great arteries. Circ J 79(11):2372–2379

    Article  PubMed  Google Scholar 

  79. Lange R, Cleuziou J, Hörer J, Holper K, Vogt M, Tassani-Prell P et al (2008) Risk factors for aortic insufficiency and aortic valve replacement after the arterial switch operation☆. Eur J Cardiothorac Surg 34(4):711–717

    Article  PubMed  Google Scholar 

  80. McMahon CJ, Ravekes WJ, O’Brian Smith E, Denfield SW, Pignatelli RH, Altman CA et al (2004) Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation. Pediatr Cardiol 25(4):329–335

    Article  CAS  PubMed  Google Scholar 

  81. Tang GHL, Borger MA (2005) Aortic root replacement surgery: indications, techniques and outcomes. Expert Rev Cardiovasc Ther 3(5):845–856

    Article  PubMed  Google Scholar 

  82. Moll JJ, Michalak KW, Młudzik K, Moszura T, Kopala M, Moll M et al (2012) Long-term outcome of direct Neopulmonary artery reconstruction during the arterial switch procedure. Ann Thorac Surg 93(1):177–184

    Article  PubMed  Google Scholar 

  83. Wernovsky G, Mayer JE, Jonas RA, Hanley FL, Blackstone EH, Kirklin JW et al (1995) Factors influencing early and late outcome of the arterial switch operation for transposition of the great arteries. J Thorac Cardiovasc Surg 109(2):289–302

    Article  CAS  PubMed  Google Scholar 

  84. Prapa M, Dimopoulos K (2012) Arterial switch repair to transposition of great arteries: so far so good. Int J Cardiol 160(1):1–3

    Article  PubMed  Google Scholar 

  85. de Koning WB, van Osch-Gevers M, Harkel ADJT, van Domburg RT, Spijkerboer AW, Utens EMWJ et al (2007) Follow-up outcomes 10 years after arterial switch operation for transposition of the great arteries: comparison of cardiological health status and health-related quality of life to those of the a normal reference population. Eur J Pediatr 167(9):995–1004

    Article  PubMed  Google Scholar 

  86. Tobler D, Williams WG, Jegatheeswaran A, Van Arsdell GS, McCrindle BW, Greutmann M et al (2010) Cardiac outcomes in young adult survivors of the arterial switch operation for transposition of the great arteries. J Am Coll Cardiol 56(1):58–64

    Article  PubMed  Google Scholar 

  87. Newburger JW, Jonas RA, Wernovsky G, Wypij D, Hickey PR, Kuban K et al (1993) A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med 329(15):1057–1064

    Article  CAS  PubMed  Google Scholar 

  88. Bellinger DC, Wypij D, duPlessis AJ, Rappaport LA, Jonas RA, Wernovsky G et al (2003) Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston circulatory arrest trial. J Thorac Cardiovasc Surg 126(5):1385–1396

    Article  PubMed  Google Scholar 

  89. Bellinger DC, Newburger JW, Wypij D, Kuban KCK, duPlesssis AJ, Rappaport LA (2008) Behaviour at eight years in children with surgically corrected transposition: the Boston Circulatory Arrest Trial. Cardiol Young 19(01):86

    Article  PubMed  PubMed Central  Google Scholar 

  90. Wypij D, Newburger JW, Rappaport LA, duPlessis AJ, Jonas RA, Wernovsky G et al (2003) The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston circulatory arrest trial. J Thorac Cardiovasc Surg 126(5):1397–1403

    Article  PubMed  Google Scholar 

  91. Bellinger DC, Wypij D, Rivkin MJ, DeMaso DR, Robertson RL, Dunbar-Masterson C et al (2011) Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure: neuropsychological assessment and structural brain imaging. Circulation 124(12):1361–1369

    Article  PubMed  PubMed Central  Google Scholar 

  92. Lynch JM, Buckley EM, Schwab PJ, McCarthy AL, Winters ME, Busch DR et al (2014) Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 148(5):2181–2188

    Article  PubMed  PubMed Central  Google Scholar 

  93. Lynch JM, Ko T, Busch DR, Newland JJ, Winters ME, Mensah-Brown K et al (2018) Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease. J Thorac Cardiovasc Surg 156:1657

    Article  PubMed  PubMed Central  Google Scholar 

  94. Mahle WT (2011) Boston circulatory arrest study at 16 years: handing over the keys. Circulation 124(12):1319–1320

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatric Cardiolgy Division, Children’s National Hospital, George Washington University, Washington, DC, USA

    Shriprasad R. Deshpande

  2. Sanger Heart and Vascular Institute, Levine Children’s Hospital, Charlotte, NC, USA

    Thomas S. Maxey & Paul M. Kirshbom

  3. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA

    Michael J. Wolf & Dennis W. Kim

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  1. Shriprasad R. Deshpande
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  2. Thomas S. Maxey
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  3. Michael J. Wolf
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  4. Dennis W. Kim
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  5. Paul M. Kirshbom
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Correspondence to Shriprasad R. Deshpande .

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Editors and Affiliations

  1. Children’s Hospital Colorado University of Colorado Denver, School of, Aurora, CO, USA

    Eduardo M. da Cruz

  2. Children's Hospital Colorado University of Colorado School of Medicin, Aurora, CO, USA

    Dunbar Ivy

  3. Department of Cardiac Surgery, German Pediatric Heart Center, Sankt Augustin, Germany

    Viktor Hraska

  4. Pediatric Cardiac Surgery, Children's Hospital Colorado University of Colorado, Aurora, CO, USA

    James Jaggers

Section Editor information

  1. The Heart Institute, Department of Pediatrics, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA

    Eduardo M. da Cruz

  2. The Heart Institute, Pediatric Cardiac Surgery, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA

    James Jaggers

  3. Cardiothoracic Surgery, University of Colorado School of Medicine The Children’s Hospital Pediatrics, Aurora, CO, USA

    James Jaggers

  4. Dept. Pediatric Cardiology, Children's Hospital Colorado, Univ. of Colorado, Denver, Aurora, Colorado, USA

    Dunbar Ivy

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Deshpande, S.R., Maxey, T.S., Wolf, M.J., Kim, D.W., Kirshbom, P.M. (2020). Simple Transposition of the Great Arteries. In: da Cruz, E.M., Ivy, D., Hraska, V., Jaggers, J. (eds) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer, London. https://doi.org/10.1007/978-1-4471-4999-6_45-2

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  • DOI: https://doi.org/10.1007/978-1-4471-4999-6_45-2

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