Abstract
Infants, children, and teens present unique challenges in the appropriate, effective, and safe use of medications and are exposed to strikingly large numbers of medications, regardless of age. It is important to base drug selection on a foundational knowledge of pharmacokinetics and pharmacodynamics. Additionally, the progress of pharmacogenomics and the promise of personalized medicine can best be understood and utilized for pediatric patients when built upon pharmacokinetics and pharmacodynamics principles, especially when incorporated with knowledge of the influence of organ maturation upon drug handling. This chapter highlights important principles of pharmacokinetics, with applications and examples to enable pediatric practitioners to enhance drug use across the continuum of pediatric ages.
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References
Feudtner C, Dai D, Hexem KR, Luan X, Metjian TA (2012) Prevalence of poly-pharmacy exposure among hospitalized children in the United States. Arch Pediatr Adolesc Med 166(1):9–16
O’Donnell JJ, O’Donnell JT, Juettner VM (2012) Clinical pharmacology for the primary care physician. Dis Mon 58:558–610
Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167
Benedetti MS, Blates EL (2003) Drug metabolism and disposition in children. Fundam Clin Pharmacol 17:281–299
Nahata MC, Taketomo C (2011) Chapter 10. Pediatrics. In: Talbert RL, DiPiro JT, Matzke GR, Posey LM, Wells BG, Yee GC (eds) Pharmacotherapy: a pathophysiologic approach, 8th edn. McGraw-Hill, New York
Lowry JA, Jones BL, Sandritter T, Liewer S, Kearns GL (2011) Chapter 57. Principles of drug therapy. In: Kliegman RM, Stanton BF, St. Gemelli JW, Schor NF, Behrman RE (eds) Nelson textbook of pediatrics, 19th edn. Elsevier/Saunders, Philadelphia
Feucht C, Patel DR (2011) Principles of pharmacology. Pediatr Clin North Am 58:11–19
Funk RS, Brown JT, Abdel-Rahman SM (2012) Pediatric pharmacokinetics: human development and drug disposition. Pediatr Clin North Am 59:1001–1006
Capparelli EV (2011) Chapter 2. Clinical pharmacokinetics in infants and children. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology: therapeutic principles in practice, 4th edn. Wolters Kluwer – Lippincott Williams & Wilkins, Philadelphia
Vetterly CG, Howrie DL (2010) A pharmacokinetic and pharmacodynamic review. In: Munoz R et al (eds) Critical care of children with heart disease: basic medical and surgical concepts. Springer, London, pp 83–87
Kauffman RE (2011) Chapter 3. Drug action and therapy in the infant and child. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology: therapeutic principles in practice, 4th edn. Wolters Kluwer – Lippincott Williams & Wilkins, Philadelphia
Anderson GD (2010) Developmental pharmacokinetics. Semin Pediatr Neurol 17:208–213
Rane A (2011) Chapter 4. Drug metabolism and disposition in infants and children. In: Yaffe SJ, Aranda JV (eds) Neonatal and pediatric pharmacology: therapeutic principles in practice, 4th edn. Wolters Kluwer – Lippincott Williams & Wilkins, Philadelphia
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Howrie, D.L., Vetterly, C.G. (2014). Pharmacokinetics and Application to Pediatric Practice. In: Da Cruz, E., Ivy, D., Jaggers, J. (eds) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer, London. https://doi.org/10.1007/978-1-4471-4619-3_60
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DOI: https://doi.org/10.1007/978-1-4471-4619-3_60
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