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Noncontrast Cardiac CT for the Detection of Calcified Atherosclerosis

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Atherosclerosis: Clinical Perspectives Through Imaging

Abstract

Noncontrast CT scanning of the chest accurately detects coronary artery calcium using multidetector CT techniques at low radiation exposure. Coronary artery calcium, quantitated using the validated area-density scoring method, is related to cardiovascular risk factors, and should be considered relative to age, gender, and ethnicity. The presence of coronary artery calcium augments the risk assessment for incident coronary heart disease independent of cardiovascular risk factors. Smaller and more diffusely distributed calcium deposits are also associated with increased cardiovascular risk, independent of the calcium score. Serial calcium scanning offers a potential method to monitor atherosclerotic risk, but more data is needed on the impact of serial imaging on cardiovascular management and outcomes.

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References

  1. Horiguchi J, Yamamoto H, Akiyama Y, Marukawa K, Hirai N, Ito K. Coronary artery calcium scoring using 16-MDCT and a retrospective ECG-gating reconstruction algorithm. AJR Am J Roentgenol. 2004;183:103–8.

    PubMed  Google Scholar 

  2. Brown ER, Kronmal RA, Bluemke DA, et al. Coronary calcium coverage score: determination, correlates, and predictive accuracy in the Multi-Ethnic Study of Atherosclerosis. Radiology. 2008;247:669–75.

    Article  PubMed  Google Scholar 

  3. Bild DE, Detrano R, Peterson D, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005; 111:1313–20.

    Article  PubMed  Google Scholar 

  4. Detrano R, Guerci AD, Carr JJ, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336–45.

    Article  PubMed  CAS  Google Scholar 

  5. Taylor AJ, Bindeman J, Feuerstein I, et al. Community-based provision of statin and aspirin after the detection of coronary artery calcium within a community-based screening cohort. J Am Coll Cardiol. 2008;51: 1337–41.

    Article  PubMed  Google Scholar 

  6. Arad Y, Spadaro LA, Roth M, Newstein D, Guerci AD. Treatment of asymptomatic adults with elevated coronary calcium scores with atorvastatin, vitamin C, and vitamin E: the St. Francis Heart Study randomized clinical trial. J Am Coll Cardiol. 2005;46:166–72.

    Article  PubMed  CAS  Google Scholar 

  7. Kronmal RA, McClelland RL, Detrano R, et al. Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2007;115:2722–30.

    Article  PubMed  Google Scholar 

  8. Raggi P, Callister TQ, Shaw LJ. Progression of coronary artery calcium and risk of first myocardial infarction in patients receiving cholesterol-lowering therapy. Arterioscler Thromb Vasc Biol. 2004;24:1272–7.

    Article  PubMed  CAS  Google Scholar 

  9. Burke AP, Taylor A, Farb A, Malcom GT, Virmani R. Coronary calcification: insights from sudden coronary death victims. Z Kardiol. 2000;89 Suppl 2:49–53.

    Article  PubMed  Google Scholar 

  10. Greenland P, Bonow RO, Brundage BH, et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. 2007;49:378–402.

    Article  PubMed  Google Scholar 

  11. McGill Jr HC, McMahan CA, Herderick EE. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 2000;20:836–45.

    Article  PubMed  Google Scholar 

  12. Witteman JC, Kannel WB, Wolf PA, et al. Aortic calcified plaques and cardiovascular disease (the Framingham Study). Am J Cardiol. 1990;66:1060–4.

    Article  PubMed  CAS  Google Scholar 

  13. Takasu J, Katz R, Nasir K, et al. Relationships of thoracic aortic wall calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2008;155:765–71.

    Article  PubMed  Google Scholar 

  14. Taylor AJ, Cerqueira M, Hodgson JM. ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Cardiovasc Comput Tomogr. 2010;4:407–33.

    PubMed  Google Scholar 

  15. McClelland RL, Chung H, Detrano R, Post W, Kronmal RA. Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2006; 113:30–7.

    Article  PubMed  Google Scholar 

  16. Polonsky TS, McClelland RL, Jorgensen NW. Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA. 2010; 303:1610–6.

    Article  PubMed  CAS  Google Scholar 

  17. Budoff MJ, Achenbach S, Blumenthal RS, et al. Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardio­vascular Imaging and Intervention, Council on Cardio­vascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. 2006;114:1761–91.

    Article  PubMed  Google Scholar 

  18. Hendel RC, Patel MR, Kramer CM, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006;48:1475–97.

    Article  PubMed  Google Scholar 

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Correspondence to Allen J. Taylor M.D., FACC, FAHA .

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Taylor, A.J. (2013). Noncontrast Cardiac CT for the Detection of Calcified Atherosclerosis. In: Taylor, A., Villines, T. (eds) Atherosclerosis: Clinical Perspectives Through Imaging. Springer, London. https://doi.org/10.1007/978-1-4471-4288-1_8

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  • DOI: https://doi.org/10.1007/978-1-4471-4288-1_8

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  • Publisher Name: Springer, London

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  • Online ISBN: 978-1-4471-4288-1

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