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Bladder Cancer

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Occupational Cancers

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Abstract

Tumors of the urinary bladder contribute significantly to the overall human cancer burden with approximately 380,000 new cases per year worldwide. Of those, around 290,000 occur in men, and about two thirds occur in more developed regions. Occupation has been identified, after smoking, as the second important risk factor for bladder cancer. Several exposures, occupations, and industries have been associated with increased bladder cancer risk. Aromatic amines (benzidine, 4-aminobiphenyl, b-naphthylamine, 4-chloro-ortho-toluidine) in dyestuff manufacture and in the rubber and other industries are the only specific agents in the workplace which have been unequivocally associated with bladder cancer in humans. Excess risks have been observed among aluminum process painters, machinists and other metal workers, workers in the textile industry, leather workers and shoemakers, printers, hairdressers, dry cleaners, and transport workers. Exposures associated with the increased risk in these occupations/industries include polycyclic aromatic hydrocarbons (PAHs), diesel engine exhaust, paints, dyes, chlorinated hydrocarbons, and other solvents, metals, and industrial oils/cutting fluids.

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Authors and Affiliations

  1. Centre for Research in Environmental Epidemiology (CREAL), 88 Dr Aiguader Rd, Barcelona, 08003, Spain

    Manolis Kogevinas MD, PhD

  2. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK

    Montserrat Garcia-Closas MD, DrPH

Authors
  1. Manolis Kogevinas MD, PhD
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  2. Montserrat Garcia-Closas MD, DrPH
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Correspondence to Manolis Kogevinas MD, PhD .

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Editors and Affiliations

  1. Helsinki University Central Hospital and Finnish Institute of Occupational Health, Helsinki, Finland

    Sisko Anttila

  2. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Paolo Boffetta

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© 2014 Springer-Verlag London

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Kogevinas, M., Garcia-Closas, M. (2014). Bladder Cancer. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_26

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  • DOI: https://doi.org/10.1007/978-1-4471-2825-0_26

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