Skip to main content
SpringerLink
Log in

Bone Grafts and Bone Graft Substitutes in Infected Arthroplasty

  • Chapter
  • First Online:
Infected Total Joint Arthroplasty

  • 1042 Accesses

Abstract

Prosthetic joint infections are associated with various degrees of bone loss. Different procedures and materials are available to fill bone defects in this setting. This chapter overviews the indications for use of bone and bone substitutes in two- and one-stage procedures, their benefits, and disadvantages. Differences in bone defect treatment in septic and aseptic revisions are discussed as well.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Achermann Y, Vogt M, et al. Characteristics and outcome of 27 elbow periprosthetic joint infection: results from a 14-year cohort study of 358 elbow prostheses. Clin Microbiol Infect. 2011;17(3):432–8.

    Article  PubMed  CAS  Google Scholar 

  2. Ammon P, Stockley I. Allograft bone in two-stage revision of the hip for infection. Is it safe? J Bone Joint Surg Br. 2004;86(7):962–5.

    Article  PubMed  CAS  Google Scholar 

  3. Aulakh TS, Jayasekera N, et al. Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty. Biomaterials. 2009;30(9):1732–8.

    Article  PubMed  CAS  Google Scholar 

  4. Baldoni D, Haschke M, et al. Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. Antimicrob Agents Chemother. 2009;53(3):1142–8.

    Article  PubMed  CAS  Google Scholar 

  5. Blom AW, Wylde V, et al. Impaction bone grafting of the acetabulum at hip revision using a mix of bone chips and a biphasic porous ceramic bone graft substitute. Acta Orthop. 2009;80(2):150–4.

    Article  PubMed  Google Scholar 

  6. Bohner M. Design of ceramic-based cements and putties for bone graft substitution. Eur Cell Mater. 2010;20:1–12.

    PubMed  CAS  Google Scholar 

  7. Brandt CM, Sistrunk WW, et al. Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clin Infect Dis. 1997;24(5):914–9.

    Article  PubMed  CAS  Google Scholar 

  8. Buchholz HW, Elson RA, et al. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop Relat Res. 1984;190:96–108.

    PubMed  Google Scholar 

  9. Buttaro MA, Pusso R, et al. Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty. Two-stage revision results. J Bone Joint Surg Br. 2005;87(3):314–9.

    Article  PubMed  CAS  Google Scholar 

  10. Clauss M, Trampuz A, et al. Biofilm formation on bone grafts and bone graft substitutes: comparison of different materials by a standard in vitro test and microcalorimetry. Acta Biomater. 2010;6(9):3791–7.

    Article  PubMed  CAS  Google Scholar 

  11. Costerton JW, Montanaro L, et al. Biofilm in implant infections: its production and regulation. Int J Artif Organs. 2005;28(11):1062–8.

    PubMed  CAS  Google Scholar 

  12. De Long Jr WG, Einhorn TA, et al. Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis. J Bone Joint Surg Am. 2007;89(3):649–58.

    Article  PubMed  Google Scholar 

  13. Ehrlich GD, Stoodley P, et al. Engineering approaches for the detection and control of orthopaedic biofilm infections. Clin Orthop Relat Res. 2005;437:59–66.

    Article  PubMed  Google Scholar 

  14. Giulieri SG, Graber P, et al. Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection. 2004;32(4):222–8.

    Article  PubMed  CAS  Google Scholar 

  15. Gristina AG. Biomaterial-centered infection: microbial adhesion versus tissue integration. Science. 1987;237(4822):1588.

    Article  PubMed  CAS  Google Scholar 

  16. Kappe T, Cakir B, et al. Infections after bone allograft surgery: a prospective study by a hospital bone bank using frozen femoral heads from living donors. Cell Tissue Bank. 2009;11(3):253–9.

    Article  PubMed  Google Scholar 

  17. Karrholm J, Hourigan P, et al. Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases. Acta Orthop. 2006;77(1):39–48.

    Article  PubMed  Google Scholar 

  18. Ketonis C, Barr S, et al. Bacterial colonization of bone allografts: establishment and effects of antibiotics. Clin Orthop Relat Res. 2010;468(8):2113–21.

    Article  PubMed  Google Scholar 

  19. Laffer RR, Graber P, et al. Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre. Clin Microbiol Infect. 2006;12(5):433–9.

    Article  PubMed  CAS  Google Scholar 

  20. Lee PT, Clayton RA, et al. Structural allograft as an option for treating infected hip arthroplasty with massive bone loss. Clin Orthop Relat Res. 2011;469(4):1016–23.

    Article  PubMed  Google Scholar 

  21. Richards RG. Final Presidential Lecture at the 19th Annual meeting European Society of Biomaterials, Lausanne. 2009.

    Google Scholar 

  22. Ritter MA, Trancik TM. Lateral acetabular bone graft in total hip arthroplasty. A three- to eight-year follow-up study without internal fixation. Clin Orthop Relat Res. 1985;193:156–9.

    PubMed  Google Scholar 

  23. Slooff TJ, Schimmel JW, et al. Cemented fixation with bone grafts. Orthop Clin North Am. 1993;24(4):667–77.

    PubMed  CAS  Google Scholar 

  24. Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury. 2006;37 Suppl 2:S59–66.

    Article  PubMed  Google Scholar 

  25. Trampuz A, Zimmerli W. Diagnosis and treatment of implant-associated septic arthritis and osteomyelitis. Curr Infect Dis Rep. 2008;10(5):394–403.

    Article  PubMed  Google Scholar 

  26. Trebse R, Pisot V, et al. Treatment of infected retained implants. J Bone Joint Surg Br. 2005;87(2):249–56.

    Article  PubMed  CAS  Google Scholar 

  27. Van De Pol GJ, Sturm PDJ, et al. Microbiological cultures of allografts of the femoral head just before transplantation. J Bone Joint Surg Br. 2007;89(9):1225.

    Article  PubMed  Google Scholar 

  28. Wahl P, Livio F, et al. Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material. Arch Orthop Trauma Surg. 2011;131(5):657–62.

    Article  PubMed  Google Scholar 

  29. Walenkamp G. Small PMMA beads improve gentamicin release. Acta Orthop Scand. 1989;60(6):668–9.

    Article  PubMed  CAS  Google Scholar 

  30. Walenkamp GH. Chronic osteomyelitis. Acta Orthop Scand. 1997;68(5):497–506.

    Article  PubMed  CAS  Google Scholar 

  31. Walenkamp GH. Self-mixed antibiotic bone cement: western countries learn from developing countries. Acta Orthop. 2009;80(5):505–7.

    Article  PubMed  Google Scholar 

  32. Winkler H. Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft. Int J Med Sci. 2009;6(5):247–52.

    Article  PubMed  CAS  Google Scholar 

  33. Winkler H, Stoiber A, et al. One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics. J Bone Joint Surg Br. 2008;90(12):1580–4.

    Article  PubMed  CAS  Google Scholar 

  34. Winter E, Piert M, et al. Allogeneic cancellous bone graft and a Burch-Schneider ring for acetabular reconstruction in revision hip arthroplasty. J Bone Joint Surg Am. 2001;83-A(6):862–7.

    PubMed  CAS  Google Scholar 

  35. Zimmerli W, Frei R, et al. Microbiological tests to predict treatment outcome in experimental device-related infections due to Staphylococcus aureus. J Antimicrob Chemother. 1994;33(5):959.

    Article  PubMed  CAS  Google Scholar 

  36. Zimmerli W, Lew PD, et al. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. J Clin Invest. 1984;73(4):1191–200.

    Article  PubMed  CAS  Google Scholar 

  37. Zimmerli W, Trampuz A, et al. Prosthetic-joint infections. N Engl J Med. 2004;351(16):1645–54.

    Article  PubMed  CAS  Google Scholar 

  38. Zimmerli W, Waldvogel FA, et al. Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis. 1982;146(4):487–97.

    Article  PubMed  CAS  Google Scholar 

  39. Zimmerli W, Widmer AF, et al. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA. 1998;279(19):1537–41.

    Article  PubMed  CAS  Google Scholar 

  40. Zofka P. Results of acetabular reconstruction with solid bone graft in primary and revision hip arthroplasty. Acta Chir Orthop Traumatol Cech. 2006;73(3):190–6.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, Kantonsspital Basel land Liestal, Rheinstrasse 26, Liestal, CH-4410, Switzerland

    Martin Clauss M.D. & Thomas Ilchmann M.D., Ph.D.

Authors
  1. Martin Clauss M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas Ilchmann M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Martin Clauss M.D. .

Editor information

Editors and Affiliations

  1. Orthopedic Hospital Valdoltra, Ankaran, 6280, Koper, Slovenia

    Rihard Trebše

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag London

About this chapter

Cite this chapter

Clauss, M., Ilchmann, T. (2012). Bone Grafts and Bone Graft Substitutes in Infected Arthroplasty. In: Trebše, R. (eds) Infected Total Joint Arthroplasty. Springer, London. https://doi.org/10.1007/978-1-4471-2482-5_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-2482-5_24

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2481-8

  • Online ISBN: 978-1-4471-2482-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation